| Espíritu Santo | |
| Subdivision Type1: | Country |
| Subdivision Name1: | Bolivia |
| Subdivision Type2: | Department |
| Subdivision Name2: | Cochabamba Department |
| Subdivision Type3: | Province |
| Subdivision Name3: | Chapare Province |
| Subdivision Type4: | Municipality |
| Subdivision Name4: | Villa Tunari Municipality |
| Length: | 66km (41miles) |
| Source1 Location: | Serranía de Callejas |
| Source1 Coordinates: | -17.1989°N -65.6864°W |
| Source1 Elevation: | 2720m (8,920feet) |
| Mouth Location: | Villa Tunari |
| Mouth Coordinates: | -16.9739°N -65.4111°W |
| Mouth Elevation: | 289m (948feet) |
| Tributaries Left: | Lima Tambo, Juntas de Corani, Blanco |
| Tributaries Right: | Jordan Mayu, Arispe Mayu, Cristal Mayito, Cristal Mayu, Huayruruny, Avispas |
The Espíritu Santo River is a Bolivian river in the Cochabamba Department, Chapare Province, Villa Tunari Municipality.[1] It belongs to the Amazon River watershed. Espíritu Santo River originates in the Callejas mountains south west of Villa Tunari. It initially flows in a northeasterly direction, before turning to the east towards Villa Tunari. In the east of the town, it meets San Matéo River which comes from the south west. From the confluence the river is known as Chapare River.