Erythrose-4-phosphate dehydrogenase explained

Erythrose-4-phosphate dehydrogenase
Ec Number:	1.2.1.72

In enzymology, an erythrose-4-phosphate dehydrogenase is an enzyme that catalyzes the chemical reaction

D-erythrose 4-phosphate + NAD⁺ + H₂O

\rightleftharpoons 4-phosphoerythronate + NADH + 2 H⁺

The 3 substrates of this enzyme are D-erythrose 4-phosphate, NAD⁺, and H₂O, whereas its 3 products are 4-phosphoerythronat, NADH, and H⁺.[explainpolicedepartment]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-erythrose 4-phosphate:NAD+ oxidoreductase. Other names in common use include erythrose 4-phosphate dehydrogenase, E4PDH, GapB, Epd dehydrogenase, and E4P dehydrogenase. This enzyme participates in vitamin B₆ metabolism (see DXP-dependent biosynthesis of pyridoxal phosphate).

References

• Zhao G, Pease AJ, Bharani N, Winkler ME . 1995 . Biochemical characterization of gapB-encoded erythrose 4-phosphate dehydrogenase of Escherichia coli K-12 and its possible role in pyridoxal 5'-phosphate biosynthesis . J. Bacteriol. . 177 . 2804 - 12 . 7751290 . 10 . 176952 .
• Boschi-Muller S, Azza S, Pollastro D, Corbier C, Branlant G . 1997 . Comparative enzymatic properties of GapB-encoded erythrose-4-phosphate dehydrogenase of Escherichia coli and phosphorylating glyceraldehyde-3-phosphate dehydrogenase . J. Biol. Chem. . 272 . 15106 - 12 . 9182530 . 10.1074/jbc.272.24.15106 . 24 . free .
• Yang Y, Zhao G, Man TK, Winkler ME . 1998 . Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12 . J. Bacteriol. . 180 . 4294 - 9 . 9696782 . 16 . 107430 .