Ervin Fodor Explained

Ervin Fodor is a British virologist of Hungarian origin born in Czechoslovakia. He is Professor of Virology holding the position of reader in experimental pathology in the Sir William Dunn School of Pathology at the University of Oxford. He is also a professorial fellow at Exeter College, Oxford.

Education

Fodor has an MSc in Chemical Engineering (Slovak University of Technology in Bratislava) and a DPhil in Pathology (University of Oxford).[1] [2]

Career

After postdoctoral studies at the Icahn School of Medicine at Mount Sinai New York and the Sir William Dunn School of Pathology at the University of Oxford, Fodor has been awarded a MRC Senior Non-Clinical Research Fellowship in 2002 followed by a RCUK Academic Fellowship in 2008.

He was appointed as university lecturer in 2011 and then as reader at the University of Oxford with the title of professor of virology.

Fodor's research focuses on the molecular biology of influenza viruses.[3] [4] [5] An early highlight of his work was the development of a reverse genetics system to generate recombinant influenza viruses following plasmid transfection.[6] This technology, developed in collaboration with Peter Palese and Adolfo García-Sastre at the Icahn School of Medicine and George Brownlee at the University of Oxford, was then used to generate live attenuated influenza virus vaccines that are also used in the UK National Childhood Flu Immunisation Programme.[7] His more recent work focuses on the molecular mechanisms used by influenza viruses to copy their genetic information stored in molecules of RNA, interactions of influenza viruses with the host cell and cellular responses to viral infection.[8] [9] [10] In collaboration with Jonathan Grimes from the Division of Structural Biology at the University of Oxford he contributed to understanding the structural basis of influenza virus RNA synthesis by solving structures of the influenza virus RNA polymerase complex.[11] [12] [13] [14]

He is the recipient of the 2019 AstraZeneca Award from the Biochemical Society.[15] The award was presented on 20–22 November 2019 in London, UK[16] at the meeting of the Biochemical Society entitled‘Transcriptions in Health and Disease’ where Fodor delivered a lecture entitled 'The influenza virus RNA polymerase'.

Fodor is a fellow of the Academy of Medical Sciences[17] and was elected as a member of EMBO in 2021.[18] [19]

Notes and References

  1. Web site: ORCID. 2021-11-12. orcid.org.
  2. Web site: Professor Ervin Fodor . 2023-01-25 . Exeter College . en-GB.
  3. Te Velthuis. Aartjan J. W.. Fodor. Ervin. August 2016. Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nature Reviews. Microbiology. 14. 8. 479–493. 10.1038/nrmicro.2016.87. 1740-1534. 4966622. 27396566.
  4. Te Velthuis. Aartjan J. W.. Grimes. Jonathan M.. Fodor. Ervin. May 2021. Structural insights into RNA polymerases of negative-sense RNA viruses. Nature Reviews. Microbiology. 19. 5. 303–318. 10.1038/s41579-020-00501-8. 1740-1534. 7832423. 33495561.
  5. Web site: Ervin Fodor : Influenza virus replication at the molecular level. . 2023-01-25 . University of Oxford Medical Sciences Division . en.
  6. Fodor. E.. Devenish. L.. Engelhardt. O. G.. Palese. P.. Brownlee. G. G.. García-Sastre. A.. November 1999. Rescue of influenza A virus from recombinant DNA. Journal of Virology. 73. 11. 9679–9682. 10.1128/JVI.73.11.9679-9682.1999. 0022-538X. 10516084. 113010 .
  7. Web site: REF Case study search. 2021-11-12. impact.ref.ac.uk. en.
  8. Te Velthuis. Aartjan J. W.. Robb. Nicole C.. Kapanidis. Achillefs N.. Fodor. Ervin. 2016-03-21. The role of the priming loop in influenza A virus RNA synthesis. Nature Microbiology. 1. 5 . 16029. 10.1038/nmicrobiol.2016.29. 2058-5276. 27572643. 4888940 .
  9. Te Velthuis. Aartjan J. W.. Long. Joshua C.. Bauer. David L. V.. Fan. Rebecca L. Y.. Yen. Hui-Ling. Sharps. Jane. Siegers. Jurre Y.. Killip. Marian J.. French. Hollie. Oliva-Martín. Maria José. Randall. Richard E.. November 2018. Mini viral RNAs act as innate immune agonists during influenza virus infection. Nature Microbiology. 3. 11. 1234–1242. 10.1038/s41564-018-0240-5. 2058-5276. 6203953. 30224800.
  10. Dadonaite. Bernadeta. Gilbertson. Brad. Knight. Michael L.. Trifkovic. Sanja. Rockman. Steven. Laederach. Alain. Brown. Lorena E.. Fodor. Ervin. Bauer. David L. V.. November 2019. The structure of the influenza A virus genome. Nature Microbiology. 4. 11. 1781–1789. 10.1038/s41564-019-0513-7. 2058-5276. 7191640. 31332385.
  11. Hengrung. Narin. El Omari. Kamel. Serna Martin. Itziar. Vreede. Frank T.. Cusack. Stephen. Rambo. Robert P.. Vonrhein. Clemens. Bricogne. Gérard. Stuart. David I.. Grimes. Jonathan M.. Fodor. Ervin. 2015-10-26. Crystal structure of the RNA-dependent RNA polymerase from influenza C virus. Nature. en. 527. 7576. 114–117. 10.1038/nature15525. 26503046 . 4783868 . 2015Natur.527..114H . 0028-0836.
  12. Serna Martin. Itziar. Hengrung. Narin. Renner. Max. Sharps. Jane. Martínez-Alonso. Mónica. Masiulis. Simonas. Grimes. Jonathan M.. Fodor. Ervin. 2018-10-18. A Mechanism for the Activation of the Influenza Virus Transcriptase. Molecular Cell. 72. 2. 396. 10.1016/j.molcel.2018.10.005. 1097-4164. 6201736. 30340026.
  13. Fan. Haitian. Walker. Alexander P.. Carrique. Loïc. Keown. Jeremy R.. Serna Martin. Itziar. Karia. Dimple. Sharps. Jane. Hengrung. Narin. Pardon. Els. Steyaert. Jan. Grimes. Jonathan M.. September 2019. Structures of influenza A virus RNA polymerase offer insight into viral genome replication. Nature. 573. 7773. 287–290. 10.1038/s41586-019-1530-7. 1476-4687. 6795553. 31485076. 2019Natur.573..287F .
  14. Carrique. Loïc. Fan. Haitian. Walker. Alexander P.. Keown. Jeremy R.. Sharps. Jane. Staller. Ecco. Barclay. Wendy S.. Fodor. Ervin. Grimes. Jonathan M.. November 2020. Host ANP32A mediates the assembly of the influenza virus replicase. Nature. 587. 7835. 638–643. 10.1038/s41586-020-2927-z. 1476-4687. 7116770. 33208942. 2020Natur.587..638C .
  15. Web site: Ervin Fodor honoured with the 2019 AstraZeneca Award Sir William Dunn School of Pathology. 2021-05-25. www.path.ox.ac.uk.
  16. Web site: The AstraZeneca Award. 2021-05-25. Biochemistry. en-GB.
  17. Web site: Professor Ervin Fodor is Elected Fellow of the Academy of Medical Sciences Sir William Dunn School of Pathology. 2021-05-25. www.path.ox.ac.uk.
  18. Web site: Professor Ervin Fodor Elected as Member of EMBO Sir William Dunn School of Pathology. 2021-11-12. www.path.ox.ac.uk.
  19. Web site: EMBO announces 64 newly elected members – Press releases – EMBO. 8 June 2021 . 2021-11-12. en-GB.

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