Equine arterivirus serine peptidase explained

Equine arterivirus serine peptidase
Ec Number:	3.4.21.114

Equine arterivirus serine peptidase is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleavage of (Glu/Gln)-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab

In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab [polyprotein]s.

Notes and References

1. Snijder EJ, Wassenaar AL, van Dinten LC, Spaan WJ, Gorbalenya AE . The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases . The Journal of Biological Chemistry . 271 . 9 . 4864–71 . March 1996 . 8617757 . 10.1074/jbc.271.9.4864 . free .
2. van Dinten LC, Rensen S, Gorbalenya AE, Snijder EJ . Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and Is essential for virus replication . Journal of Virology . 73 . 3 . 2027–37 . March 1999 . 10.1128/JVI.73.3.2027-2037.1999 . 9971783 . 104445 .
3. Barrette-Ng IH, Ng KK, Mark BL, Van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ, James MN . Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole . The Journal of Biological Chemistry . 277 . 42 . 39960–6 . October 2002 . 12163505 . 10.1074/jbc.m206978200 . free .