Equine arteritis virus leader TRS hairpin (LTH) explained
| Equine arteritis virus leader TRS hairpin (LTH) |
| Symbol: | EAV_LTH |
| Rfam: | RF00498 |
| Rna Type: | Cis-reg; leader |
| Tax Domain: | Viruses |
The equine arteritis virus leader transcription-regulating sequence hairpin (LTH) is as RNA element that is thought to be a key structural element in discontinuous subgenomic RNA synthesis and is critical for leader transcription-regulating sequences (TRS) function.[1] Similar structures have been predicted in other arteriviruses and coronaviruses.[2]
Notes and References
- Van Den Born E, Gultyaev AP, Snijder EJ . Secondary structure and function of the 5'-proximal region of the equine arteritis virus RNA genome . RNA . 10 . 3 . 424–437 . March 2004 . 14970388 . 1370938 . 10.1261/rna.5174804 .
- Liu Y, Wimmer E, Paul AV . Cis-acting RNA elements in human and animal plus-strand RNA viruses . Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms . 1789 . 9–10 . 495–517 . 2009 . 19781674 . 2783963 . 10.1016/j.bbagrm.2009.09.007 .
