Equilibrative nucleoside transporter 2 explained

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.^{[1] [2] [3]}

See also

• Solute carrier family
• Equilibrative nucleoside transporters
• Nucleoside transporters

Further reading

• Baldwin SA, Beal PR, Yao SY . The equilibrative nucleoside transporter family, SLC29. . Pflügers Arch. . 447 . 5 . 735–43 . 2004 . 12838422 . 10.1007/s00424-003-1103-2 . 8817821 . etal.
• Mangravite LM, Badagnani I, Giacomini KM . Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney . Eur. J. Pharmacol. . 479 . 1–3 . 269–81 . 2004 . 14612157 . 10.1016/j.ejphar.2003.08.076 .
• Williams JB, Lanahan AA . A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein. . Biochem. Biophys. Res. Commun. . 213 . 1 . 325–33 . 1995 . 7639753 . 10.1006/bbrc.1995.2133 . free .
• Griffiths M, Yao SY, Abidi F . Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. . Biochem. J. . 328 . 3. 739–43 . 1998 . 9396714 . 10.1042/bj3280739. 1218980. etal.
• Yao SY, Ng AM, Vickers MF . Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. . J. Biol. Chem. . 277 . 28 . 24938–48 . 2002 . 12006583 . 10.1074/jbc.M200966200 . etal. free .
• Molina-Arcas M, Bellosillo B, Casado FJ . Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. . Blood . 101 . 6 . 2328–34 . 2003 . 12411296 . 10.1182/blood-2002-07-2236 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Mangravite LM, Xiao G, Giacomini KM . Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. . Am. J. Physiol. Renal Physiol. . 284 . 5 . F902–10 . 2003 . 12527552 . 10.1152/ajprenal.00215.2002 .
• Ward JL, Leung GP, Toan SV, Tse CM . Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. . Arch. Biochem. Biophys. . 411 . 1 . 19–26 . 2003 . 12590919 . 10.1016/S0003-9861(02)00718-X .
• Szkotak AJ, Ng AM, Man SF . Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. . J. Membr. Biol. . 192 . 3 . 169–79 . 2003 . 12820662 . 10.1007/s00232-002-1073-x . 23060872 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Farré X, Guillén-Gómez E, Sánchez L . Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. . Int. J. Cancer . 112 . 6 . 959–66 . 2004 . 15386342 . 10.1002/ijc.20524 . 33828164 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Visser F, Zhang J, Raborn RT . Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites. . Mol. Pharmacol. . 67 . 4 . 1291–8 . 2005 . 15644498 . 10.1124/mol.104.005884 . 22594104 . etal.
• Visser F, Baldwin SA, Isaac RE . Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters. . J. Biol. Chem. . 280 . 12 . 11025–34 . 2005 . 15649894 . 10.1074/jbc.M410348200 . etal. free .
• Owen RP, Lagpacan LL, Taylor TR . Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. . Drug Metab. Dispos. . 34 . 1 . 12–5 . 2006 . 16214850 . 10.1124/dmd.105.006270 . 6396393 . etal.

Notes and References

1. Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, ((Phillips JA III)), Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS . The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome . Genomics . 42 . 2 . 325–30 . Sep 1997 . 9192854 . 10.1006/geno.1997.4751 .
2. Crawford CR, Patel DH, Naeve C, Belt JA . Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line . J Biol Chem . 273 . 9 . 5288–93 . Mar 1998 . 9478986 . 10.1074/jbc.273.9.5288. free .
3. Web site: Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2.