Eprotirome Explained

Cas Number:355129-15-6
Chembl:2035874
Chemspiderid:8475344
Pubchem:10299876
Unii:958AQ7B6R1
Drugbank:DB05035
Stdinchi:1S/C18H17Br2NO5/c1-9(2)12-7-11(3-4-15(12)22)26-18-13(19)5-10(6-14(18)20)21-16(23)8-17(24)25/h3-7,9,22H,8H2,1-2H3,(H,21,23)(H,24,25)
Stdinchikey:VPCSYAVXDAUHLT-UHFFFAOYSA-N
Smiles:CC(C)C1=C(C=CC(=C1)OC2=C(C=C(C=C2Br)NC(=O)CC(=O)O)Br)O
Iupac Name:2-(carbamoyl)acetic acid
C:18
H:17
Br:2
N:2
O:5

Eprotirome is a thyromimetic drug that has been investigated for the treatment of dyslipidemia. A Phase III trial in humans was discontinued after the drug was found to have negative effects on cartilage in dogs.[1] [2]

Notes and References

  1. Saponaro . Federica . Sestito . Simona . Runfola . Massimiliano . Rapposelli . Simona . Chiellini . Grazia . Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders . Frontiers in Medicine . 2020 . 7 . 331 . 10.3389/fmed.2020.00331 . 32733906 . 7363807 . 2296-858X . free .
  2. Unnikrishnan . A. G. . Baruah . Manash . Kalra . Sanjay . Thyromimetics: What does the future hold? . Indian Journal of Endocrinology and Metabolism . December 2012 . 16 . Suppl 2 . S159–S161 . 10.4103/2230-8210.104029 . 23565368 . 3603016 . 2230-8210 . free .