Eprobemide Explained

Eprobemide (INN) is a pharmaceutical drug that was used as an antidepressant in Russia (under the brand name Бефол/Befol).^[1] It is a non-competitive reversible inhibitor of monoamine oxidase A^{[2] [3]} that exhibits selective action on serotonin deamination.^[4] Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.^[5]

Notes and References

1. Book: Dictionary of Pharmacological Agents . 3 . Ganellin CR, Triggle DJ . 811 . 1996 . 978-0412466304.
2. Gol'dina OA, Moskvitina TA, Gankina EM, Kirkel' AZ, Kamyshanskaia NS, Lopatina KI, Sokolova TV, Zagorevskiĭ VA, Val'dman AV, Gorkin VZ . 6 . [The action of befol and its derivatives on monoamine oxidase of different origins] . Biulleten' Eksperimental'noi Biologii I Meditsiny . 111 . 3 . 279–80 . March 1991 . 2054504 .
3. Donskaya NS, Antonkina OA, Glukhan EN, Smirnov SK . Antidepressant Befol Synthesized Via Interaction of 4-Chloro-N-(3-chloropropyl)benzamide with Morpholine. Pharmaceutical Chemistry Journal . 2004-07-01 . 38 . 0091-150X . 7 . 381–384 . 10.1023/B:PHAC.0000048439.38383.5f . 29121452.
4. Web site: Eprobemide . ChemIDplus .
5. Web site: Befol . 4DOKTOR.RU Drug Information Handbook. 4 February 2014. Russian.