Epinastine Explained

Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.[1] It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.[2]

It was patented in 1980 and came into medical use in 1994.[3]

Notes and References

  1. Pradhan S, Abhishek K, Mah F . Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects . Expert Opinion on Drug Metabolism & Toxicology . 5 . 9 . 1135–1140 . September 2009 . 19630694 . 10.1517/17425250903117284 . 207490591 .
  2. Walther G, Daniel H, Bechtel WD, Brandt K . New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine . Arzneimittel-Forschung . 40 . 4 . 440–446 . April 1990 . 1972625 .
  3. Book: Fischer J, Ganellin CR . Analogue-based Drug Discovery . 2006 . John Wiley & Sons . 9783527607495 . 549 . en.

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