| Honorific Prefix: | Doctor of Medicine |
| Epifanio Ferdinando | |
| Birth Date: | 1569 11, df=y |
| Birth Place: | Mesagne, Kingdom of Naples |
| Death Place: | Mesagne, Kingdom of Naples |
| Nationality: | Italian |
| Occupation: | Physician |
| Children: | 10 |
| Parents: | Matteo Ferdinando and Camilla Ferdinando (née Rini) |
| Alma Mater: | University of Naples Federico II |
| Discipline: | Physician |
| Influenced: | Athanasius Kircher |
Epifanio Ferdinando (1569–1638) was an Italian physician of the Renaissance. He is known to medical historians for his detailed discussion of tarantism.
Epifanio Ferdinando was born in Mesagne, in the Terra di Otranto, on 2 November 1569. He cultivated the study of the Latin and Greek poets at an early age, and wrote elegant verses in both these languages. In 1583 he went to Naples with the intention of going through the courses of philosophy and medicine; but in 1591, all strangers were compelled to leave the place. Ferdinando, returning to his own country, taught geometry and philosophy until 1594, when the viceroy's edict being revoked, he returned to Naples, pursued a course of medical studies, and received the degree of doctor in medicine and philosophy. He then returned to his native home, where he settled himself and remained to the end of his life, notwithstanding the tempting offers he received from several universities. The Duke of Parma Ranuccio Farnese, in particular, pressed him to take the professorship of medicine in the university of his city; and the same invitation, was given from the University of Padua. In 1605, he was elected syndic-general of his country. He died in Mesagne on 6 December 1638, aged 69.
Epifanio Ferdinando composed a considerable number of treatises, but only the four following are known, as having been printed: