Epietiocholanolone Explained

Epietiocholanolone, also known as 3β-hydroxy-5β-androstan-17-one or as etiocholan-3β-ol-17-one, is an etiocholane (5β-androstane) steroid as well as an inactive metabolite of testosterone that is formed in the liver.[1] [2] [3] The metabolic pathway is testosterone to 5β-dihydrotestosterone (via 5β-reductase), 5β-dihydrotestosterone to 3β,5β-androstanediol (via 3β-hydroxysteroid dehydrogenase), and 3β,5β-androstanediol to epietiocholanolone (via 17β-hydroxysteroid dehydrogenase). Epietiocholanolone can also be formed directly from 5β-androstanedione (via 3β-hydroxysteroid dehydrogenase).[4] It is glucuronidated and sulfated in the liver and excreted in urine.[5]

See also

Notes and References

  1. Book: Arun Nagrath. Narendra Malhotra. Seth Shikha. Progress in Obstetrics & Gynecology. 31 July 2012. JP Medical Ltd. 978-93-5025-779-1. 265–.
  2. Book: J. Horsky. J. Presl. Ovarian Function and its Disorders: Diagnosis and Therapy. 6 December 2012. Springer Science & Business Media. 978-94-009-8195-9. 107–.
  3. Book: MORFIN Robert. Les stéroïdes naturels de A à Z. 20 December 2010. Lavoisier. 978-2-7430-1918-1. 428–.
  4. Book: Hugh L. J. Makin. D.B. Gower. Steroid Analysis. 4 June 2010. Springer Science & Business Media. 978-1-4020-9775-1. 462–.
  5. Hauser B, Deschner T, Boesch C . Development of a liquid chromatography-tandem mass spectrometry method for the determination of 23 endogenous steroids in small quantities of primate urine . J. Chromatogr. B . 862 . 1–2 . 100–12 . 2008 . 18054529 . 10.1016/j.jchromb.2007.11.009 .

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