Epi-isozizaene synthase explained

epi-isozizaene synthase
Ec Number:	4.2.3.37

epi-Isozizaene synthase (EC 4.2.3.37, SCO5222 protein) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epi-isozizaene-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate

\rightleftharpoons (+)-epi-isozizaene + diphosphate

This enzyme requires Mg²⁺ for activity.

Notes and References

1. Lin X, Hopson R, Cane DE . Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase . Journal of the American Chemical Society . 128 . 18 . 6022–3 . May 2006 . 16669656 . 2533732 . 10.1021/ja061292s .
2. Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE . Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2) . The Journal of Biological Chemistry . 283 . 13 . 8183–9 . March 2008 . 18234666 . 2276382 . 10.1074/jbc.M710421200 . free .