| Ephraim L. Van Winkle | |
| Office1: | Secretary of State of Kentucky |
| Office2: | Member of the Kentucky General Assembly |
| Order1: | 40th |
| Termend1: | May 23, 1866 |
| Termstart1: | September 1, 1863 |
| Termstart2: | 1855 |
| Termend2: | 1856 |
| Birth Date: | 20 July 1827 |
| Birth Place: | Wayne County, Kentucky, U.S. |
| Party: | Unknown (most likely Whig) |
| Parents: | Micajah Van Winkle Mary Phillips |
| Education: | Monticello Academy University of Louisville |
| Preceded1: | Daniel C. Wickliffe |
| Succeeded1: | John S. Van Winkle |
| Governor1: | Thomas E. Bramlette |
Ephraim L. Van Winkle (July 20, 1827 – May 23, 1866) was an American politician who served as Secretary of State of Kentucky from 1863 until his death in 1866. He was most likely a member of the Whig Party.
Ephraim L. Van Winkle was born on July 20, 1827, in Wayne County, Kentucky, to Micajah Van Winkle and Mary Phillips. He attended Monticello University and graduated from the University of Louisville's law department in 1850.[1]
After graduating, Van Winkle began practicing law in Wayne County. In 1855, he was elected to the Kentucky General Assembly, Which he served on for at least a year until he was elected Commonwealth attorney for the 6th district in 1856. In 1860, Van Winkle was a Presidential elector for the John Bell and Edward Everett slate.
In 1863, Van Winkle was appointed Secretary of State of Kentucky by governor Thomas E. Bramlette.[2] He had emancipationist beliefs.
Van Winkle died on May 23, 1866, at the age of 38. He was interred in Frankfort, Kentucky. His position as Secretary of State of Kentucky was filled by his brother John S. Van Winkle.[3]