Epaminurad Explained

Cas Number:1198153-15-9
Pubchem:44608229
Chemspiderid:35143241
Unii:0YP1ME85GH
Chembl:4640580
Synonyms:URC102/UR-1102
Iupac Name:(3,5-dibromo-4-hydroxyphenyl)-(2,3-dihydropyrido[4,3-b][1,4]oxazin-4-yl)methanone| C=14 | H=10 | Br=2 | N=2 | O=3| molecular_weight = | SMILES = C1COC2=C(N1C(=O)C3=CC(=C(C(=C3)Br)O)Br)C=NC=C2| Jmol = | StdInChI = InChI=1S/C14H10Br2N2O3/c15-9-5-8(6-10(16)13(9)19)14(20)18-3-4-21-12-1-2-17-7-11(12)18/h1-2,5-7,19H,3-4H2| StdInChI_comment = | StdInChIKey = ZMVGQIIOXCGAFV-UHFFFAOYSA-N| density = | density_notes = | melting_point = | melting_high = | melting_notes = | boiling_point = | boiling_notes = | solubility = | sol_units = | specific_rotation = }}Epaminurad is an investigational new drug being developed by JW Pharmaceutical for the treatment of gout and hyperuricemia. It is a urate-lowering agent that selectively inhibits the human uric acid transporter 1 (hURAT1), promoting urate excretion.[1] [2] As of 2024, epaminurad is undergoing Phase 3 clinical trials to evaluate its efficacy and safety compared to febuxostat in gout patients across multiple Asian countries.[3]

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Notes and References

  1. Web site: JW Pharmaceutical's Epaminurad Shows Promise for Gout Treatment . Business Korea . 16 January 2024 . 2024-11-23.
  2. Hou X, Wang Y, Yang Y, Xiao Z . Discovery of Novel Biphenyl Carboxylic Acid Derivatives as Potent URAT1 Inhibitors . Molecules . Basel, Switzerland . 28 . 21 . November 2023 . 7415 . 37959834 . 10648204 . 10.3390/molecules28217415 . free .
  3. Web site: Khaja H . Emerging Drug Treatments for Gout . Rheumatology Advisor . 9 February 2024 . 2024-11-23.