Enzo Emanuele Explained

Enzo Emanuele
Birth Date:	10 June 1977
Birth Place:	Novara, Italy
Field:	Clinical Pathology
Alma Mater:	Pavia Medical School - University of Pavia
Known For:	Biomarker discovery, Interdisciplinary research
Prizes:	Zdenek Klein Award for Human Ethology (2008), Giovanni Galli Prize for the Study of Atherosclerosis (2009)

Enzo Emanuele (born June 10, 1977) is an Italian clinical pathologist known for his interdisciplinary research in the field of biological psychology. He has studied the biochemical basis of romantic interpersonal attraction and identified the neurotrophin nerve growth factor (NGF) as a key biochemical mediator of falling in love.^[1] The implications of this research have been criticized in the popular press.^[2] In 2008, his genetic research, which showed an association between serotonin and dopamine receptor gene polymorphisms and certain love traits,^[3] was awarded with the International Zdenek Klein Award for Human Ethology from Charles University in Prague, Czech Republic.^[4]

Emanuele is also known for his studies on biomarkers of atherosclerosis.^[4] On October 3, 2009, Enzo Emanuele was awarded by the Italian Society for the Study of Atherosclerosis (SISA), Lombardy Section, with the Giovanni Galli Prize for his scientific contributions in the field of cardiovascular biomarkers.^[5]

He graduated as MD from the University of Pavia in Pavia, Italy^[4] in 2002.^[6]

Emanuele is Associate Editor of the journal Atherosclerosis.^[4] He is also member of the editorial board of the Journal of Special Education and Rehabilitation.^[7]

Contributions to science

• Identification of sRAGE, the soluble form of the receptor for advanced glycation endproducts, as related to atherosclerosis,^[8] dementia,^[9] and longevity.^[10]
• Identification of the neurotrophin nerve growth factor (NGF) as a biochemical mediator of falling in love in humans.^[11]
• Genetic dissection of human mating system and love styles.^[3]
• Identification of biochemical markers of autism.^{[12] [13]}
• Genetics of sporadic Alzheimer's disease.^{[14] [15]}
• Identification of biochemical markers related to aggressive behaviour in domestic animals.^{[16] [17]}
• Role of serotonin and omega-3 fatty acids in experimental neuroeconomics.^{[18] [19]}
• Researchers led by Dr Enzo Emanuele have traced the genetic component of cellulite to particular polymorphisms in the angiotensin converting enzyme (ACE) and hypoxia-inducible factor 1A (HIF1a) genes.^[20]

External links

• The European Atherosclerosis Society
• Associate Editors of Atherosclerosis
• Zdenek Klein Award for Human Ethology

Notes and References

1. Emanuele E, Politi P, Bianchi M, Minoretti P, Bertona M, Geroldi D . Raised plasma nerve growth factor levels associated with early-stage romantic love . Psychoneuroendocrinology . 31 . 3 . 288–94 . Apr 2006 . 16289361 . 10.1016/j.psyneuen.2005.09.002 . 18497668 . 0306-4530.
   • Web site: Sam Savage . 29 November 2005 . Molecule Gives Passionate Lovers Just One Year . Red Orbit .
2. News: John . Harris . Is love just a chemical? . . 29 November 2005 . 28 August 2009.
3. 18063936 . Dec 2007 . Genetic loading on human loving styles . 28 . 6 . 815–21 . 0172-780X . Neuro Endocrinology Letters . Emanuele, E . Brondino, N . Pesenti, S . Re, S . Geroldi, D.
4. Web site: Associate Editors . European Atherosclerosis Society . 24 March 2010 .
5. Web site: Giovanni Galli Prize . Italian Society for the Study of Atherosclerosis (SISA), Lombardy Section . 6 October 2009 . It . dead . https://web.archive.org/web/20110722053006/http://www.sisalombardia.it/congresso2009/premioggalli09.htm . 22 July 2011 .
6. http://application.fnomceo.it/Fnomceo/public/dettagliProfessionista.ot?id=56225 Page at Italian Federation of Medical Associations (FNOMCeO)
7. Web site: Editorial Board of the Journal of Special Education and Rehabilitation . 2009-10-12 . https://web.archive.org/web/20090916205236/http://jser.fzf.ukim.edu.mk/index.php?option=com_content&view=article&id=113&Itemid=64 . 2009-09-16 . dead .
8. 15731496 . May 2005 . Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men . 25 . 5 . 1032–7 . 1079-5642 . 10.1161/01.ATV.0000160342.20342.00 . Arteriosclerosis, Thrombosis, and Vascular Biology . Free full text . Falcone, C . Emanuele, E . D'angelo, A . Buzzi, Mp . Belvito, C . Cuccia, M . Geroldi, D . 10.1.1.572.867 . 18192387 . 2009-08-25 . https://archive.today/20120701132924/http://atvb.ahajournals.org/cgi/pmidlookup?view=long&pmid=15731496 . 2012-07-01 . dead .
9. 16286548 . Nov 2005 . Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia . 62 . 11 . 1734–6 . 0003-9942 . 10.1001/archneur.62.11.1734 . Archives of Neurology . Emanuele, E . D'angelo, A . Tomaino, C . Binetti, G . Ghidoni, R . Politi, P . Bernardi, L . Maletta, R . Bruni, Ac . Geroldi, D .
10. 16866696 . Jul 2006 . High levels of soluble receptor for advanced glycation end products may be a marker of extreme longevity in humans . 54 . 7 . 1149–50 . 0002-8614 . 10.1111/j.1532-5415.2006.00776.x . Journal of the American Geriatrics Society . Geroldi, D . Falcone, C . Minoretti, P . Emanuele, E . Arra, M . D'angelo, A. 6142613 .
11. 16289361 . Apr 2006 . Raised plasma nerve growth factor levels associated with early-stage romantic love . 31 . 3 . 288–94 . 0306-4530 . 10.1016/j.psyneuen.2005.09.002 . Psychoneuroendocrinology . Emanuele, E . Politi, P . Bianchi, M . Minoretti, P . Bertona, M . Geroldi, D. 18497668 .
12. 17101220 . Dec 2006 . Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autism . 410 . 3 . 169–73 . 0304-3940 . 10.1016/j.neulet.2006.08.092 . Neuroscience Letters . Boso, M . Emanuele, E . Minoretti, P . Arra, M . Politi, P . Ucelli, Di . Barale, F. 20272562 .
13. 17174726 . Jan 2007 . Reduced plasma apelin levels in patients with autistic spectrum disorder . 38 . 1 . 70–4 . 0188-4409 . 10.1016/j.arcmed.2006.08.003 . Archives of Medical Research . Boso, M . Emanuele, E . Politi, P . Pace, A . Arra, M . Ucelli, Di . Barale, F.
14. 19664850 . Aug 2009 . Chromosome 9p21.3 genotype is associated with vascular dementia and Alzheimer's disease . 32. 7. 1231–5. 0197-4580 . 10.1016/j.neurobiolaging.2009.07.003 . Neurobiology of Aging . Emanuele, E . Lista, S . Ghidoni, R . Binetti, G . Cereda, C . Benussi, L . Maletta, R . Bruni, Ac . Politi, P . 635821 .
15. 17090974 . 2007 . The M694V variant of the familial Mediterranean fever gene is associated with sporadic early-onset Alzheimer's disease in an Italian population sample . 23 . 1 . 55–9 . 1420-8008 . 10.1159/000096743 . Dementia and Geriatric Cognitive Disorders . Arra, M . Emanuele, E . Martinelli, V . Minoretti, P . Bertona, M . Geroldi, D. 44605756 .
16. 10.1007/s10164-007-0079-3 . Association of inflammatory markers elevation with aggressive behavior in domestic dogs . 2009 . Re, Simona . Journal of Ethology . 27 . 31–33 . Zanoletti . Marco . Emanuele . Enzo. 6585126 .
17. 17891468 . Mar 2008 . Aggressive dogs are characterized by low omega-3 polyunsaturated fatty acid status . 32 . 3 . 225–30 . 0165-7380 . 10.1007/s11259-007-9021-y . Veterinary Research Communications . Re, S . Zanoletti, M . Emanuele, E. 21948930 .
18. 18448251 . May 2008 . Relationship between platelet serotonin content and rejections of unfair offers in the ultimatum game . 437 . 2 . 158–61 . 0304-3940 . 10.1016/j.neulet.2008.04.006 . Neuroscience Letters . Emanuele, E . Brondino, N . Bertona, M . Re, S . Geroldi, D. 11537582 .
19. 18940191 . Jan 2009 . Serum omega-3 fatty acids are associated with ultimatum bargaining behavior . 96 . 1 . 180–3 . 0031-9384 . 10.1016/j.physbeh.2008.09.020 . Physiology & Behavior . Emanuele, E . Brondino, N . Re, S . Bertona, M . Geroldi, D. 17638261 .
20. Emanuele E, Bertona M, Geroldi D . A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite . Journal of the European Academy of Dermatology and Venereology . 2010 . 10.1111/j.1468-3083.2009.03556.x . https://archive.today/20121210072909/http://www3.interscience.wiley.com/cgi-bin/fulltext/123234684/HTMLSTART. dead. 2012-12-10. 20059631. 24. 8. 930–5. 26214159 .