Enterovirus cis-acting replication element explained

Enterovirus cis-acting replication element
Symbol:	Entero_CRE
Altsymbols:	CRE
Rfam:	RF00048
Rna Type:	Cis-reg
Tax Domain:	Viruses

Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation.^{[1] [2]} The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.

See also

• Enteroviral 3′ UTR element
• Enterovirus 5′ cloverleaf cis-acting replication element

Notes and References

1. Paul AV, Rieder E, Kim DW, van Boom JH, Wimmer E . Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg . Journal of Virology . 74 . 22 . 10359–10370 . November 2000 . 11044080 . 110910 . 10.1128/JVI.74.22.10359-10370.2000 .
2. Goodfellow I, Chaudhry Y, Richardson A, Meredith J, Almond JW, Barclay W, Evans DJ . Identification of a cis-acting replication element within the poliovirus coding region . Journal of Virology . 74 . 10 . 4590–4600 . May 2000 . 10775595 . 111979 . 10.1128/JVI.74.10.4590-4600.2000 .