Enterovirus 5′ cloverleaf cis-acting replication element explained

Enterovirus 5′ cloverleaf cis-acting replication element
Symbol:	Entero_5_CRE
Rfam:	RF00386
Rna Type:	Cis-reg
Tax Domain:	Viruses

The Enterovirus 5′ cloverleaf cis-acting replication element is an RNA element found in the 5′ UTR of Enterovirus genomes. The element has a cloverleaf like secondary structure and is known to be a multifunctional cis-acting replication element (CRE), required for the initiation of negative strand RNA synthesis.^[1]

See also

• Enteroviral 3′ UTR element
• Enterovirus cis-acting replication element

Notes and References

1. Barton DJ, O'Donnell BJ, Flanegan JB . 5′ cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis . The EMBO Journal . 20 . 6 . 1439–1448 . March 2001 . 11250909 . 145522 . 10.1093/emboj/20.6.1439 .