Enteric glia explained
The enteric glia, enteric glial cells or EGCs are a population of neuroglial cells that populate the enteric nervous system.[1]
These cells are one of the major neural-crest-derived cell lineages, found throughout the gastrointestinal tract. The enteric glial cells play a variety of roles, such as modulating nociception (pain sensation), exerting immune functions, and coordingating gastrointestinal motility.[2] [3] They are the largest glial population outside the brain, and considered "a key node of the gut-brain axis".[4]
Notes and References
- Liu . Chang . Yang . Jing . 2022-04-28 . Enteric Glial Cells in Immunological Disorders of the Gut . Frontiers in Cellular Neuroscience . English . 16 . 10.3389/fncel.2022.895871 . free . 35573829 . 9095930 . 1662-5102.
- Morales-Soto . Wilmarie . Gonzales . Jacques . Jackson . William F. . Gulbransen . Brian D. . 2023-11-21 . Enteric glia promote visceral hypersensitivity during inflammation through intercellular signaling with gut nociceptors . Science Signaling . en . 16 . 812 . eadg1668 . 10.1126/scisignal.adg1668 . 1945-0877 . 37988454. 10733972 .
- Scavuzzo . Marissa A. . Letai . Katherine C. . Maeno-Hikichi . Yuka . Wulftange . William J. . Shah . Isha K. . Rameshbabu . Jeyashri S. . Tomar . Alka . Shick . H. Elizabeth . Shah . Aakash K. . Xiong . Ying . Cohn . Erin F. . Allan . Kevin C. . Tesar . Paul J. . 2023-06-09 . Enteric glial hub cells coordinate intestinal motility . bioRxiv . 2023.06.07.544052 . 10.1101/2023.06.07.544052 . 37333182. 10274798 .
- Rosenberg . Harry J. . Rao . Meenakshi . August 2021 . Enteric glia in homeostasis and disease: From fundamental biology to human pathology . iScience . 24 . 8 . 102863 . 10.1016/j.isci.2021.102863 . 2589-0042 . 8348155 . 34401661. 2021iSci...24j2863R .
