In the 1570s Squirrel made a return voyage from England to Narragansett Bay, piloted by Simon Fernandes.[1] The voyage was considered remarkable given her small size and the dangers of sailing in largely uncharted waters.
She was one of a small fleet of vessels under the command of Sir Humphrey Gilbert, commissioned in 1579 by the lord deputy of Ireland, William Drury, to attack James FitzMaurice FitzGerald by sea and to intercept a fleet expected to arrive from Spain. The expedition was a failure with the fleet dispersed by heavy seas and forced to seek shelter at Land's End.
Squirrel was again under Gilbert's command in 1583 for a voyage to Newfoundland and the eastern coast of North America. Departing England in June in company with four other vessels, she made an uneventful crossing of the Atlantic and reached the Newfoundland coast on 5 August. Gilbert went ashore at St John's to claim the area as England's first overseas colony under Royal Charter of Queen Elizabeth I.[2] Plans for a further expedition south along the American coastline were abandoned following a critical shortage of supplies, and Gilbert elected instead to return to England.[3] Squirrel was selected as the flagship for this return voyage and was armed with some small cannon, in Gilbert's words "more to give a show [of force] than with judgement to foresee unto the safety of her and the men."[3]
On 9 September Squirrel had reached the Azores off the European coast when she ran into a storm and was lost with all hands.[4] News of her fate was carried to England by the crew of Golden Hind, another vessel in Gilbert's fleet and the only one to survive the return voyage.[5]