Enduracididine Explained

Enduracididine is a non-proteinogenic α-amino acid that is a cyclic analogue of arginine.[1] It is not genetically encoded into peptide sequences, but rather is generated as a posttranslational modification.

Biological roles

Enduracididine occurs rarely in nature, appearing principally in peptide antibiotics such as the antibacterial compounds enramycin and teixobactin.[2]

Notes and References

  1. Atkinson. DJ. Naysmith. BJ. Furkert. DP. Brimble. MA. Enduracididine, a rare amino acid component of peptide antibiotics: Natural products and synthesis.. Beilstein J Org Chem. 7 November 2016. 12. 2325–2342. 28144300. 10.3762/bjoc.12.226. 5238550.
  2. Ling. LL. Schneider. T. Peoples. AJ. Spoering. AL. Engels. I. Conlon. BP. Mueller. A. Schäberle. TF. Hughes. DE. Epstein. S. Jones. M. Lazarides. L. Steadman. VA. Cohen. DR. Felix. CR. Fetterman. KA. Millett. WP. Nitti. AG. Zullo. AM. Chen. C. Lewis. K. A new antibiotic kills pathogens without detectable resistance.. Nature. 22 January 2015. 517. 7535. 455–9. 25561178. 10.1038/nature14098. 7414797.

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