Endothelin A receptor explained

Endothelin receptor type A, also known as ET_A, is a human G protein-coupled receptor.^[1]

Interactions

Endothelin receptor type A has been shown to interact with HDAC7A^[2] and HTATIP.^[2]

See also

• Endothelin receptor

External links

• Web site: Endothelin Receptors: ET_A . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Further reading

• Arai H, Nakao K, Hosoda K, Ogawa Y, Nakagawa O, Komatsu Y, Imura H . [Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells] . Japanese Circulation Journal . 56 . 1303–7 . 1993 . Suppl 5 . 1291713 . 10.1253/jcj.56.supplementv_1303 . free .
• Hosoda K, Nakao K, Tamura N, Arai H, Ogawa Y, Suga S, Nakanishi S, Imura H . Organization, structure, chromosomal assignment, and expression of the gene encoding the human endothelin-A receptor . The Journal of Biological Chemistry . 267 . 26 . 18797–804 . September 1992 . 10.1016/S0021-9258(19)37031-0 . 1326535 . free .
• Hayzer DJ, Rose PM, Lynch JS, Webb ML, Kienzle BK, Liu EC, Bogosian EA, Brinson E, Runge MS . Cloning and expression of a human endothelin receptor: subtype A . The American Journal of the Medical Sciences . 304 . 4 . 231–8 . October 1992 . 1415318 . 10.1097/00000441-199210000-00002 .
• Hosoda K, Nakao K, Suga S, Ogawa Y, Mukoyama M, Shirakami G, Saito Y, Nakanishi S, Imura H . Cloning and expression of human endothelin-1 receptor cDNA . FEBS Letters . 287 . 1–2 . 23–6 . August 1991 . 1652463 . 10.1016/0014-5793(91)80007-P . 908246 . free .
• Cyr C, Huebner K, Druck T, Kris R . Cloning and chromosomal localization of a human endothelin ETA receptor . Biochemical and Biophysical Research Communications . 181 . 1 . 184–90 . November 1991 . 1659806 . 10.1016/S0006-291X(05)81399-3 . free .
• Adachi M, Yang YY, Furuichi Y, Miyamoto C . Cloning and characterization of cDNA encoding human A-type endothelin receptor . Biochemical and Biophysical Research Communications . 180 . 3 . 1265–72 . November 1991 . 1719979 . 10.1016/S0006-291X(05)81332-4 .
• Lin HY, Kaji EH, Winkel GK, Ives HE, Lodish HF . Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor . Proceedings of the National Academy of Sciences of the United States of America . 88 . 8 . 3185–9 . April 1991 . 1849646 . 51410 . 10.1073/pnas.88.8.3185 . 1991PNAS...88.3185L . free .
• Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K . Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors . European Journal of Biochemistry . 228 . 1 . 102–8 . February 1995 . 7882989 . 10.1111/j.1432-1033.1995.tb20236.x .
• Kobayashi S, Tang R, Wang B, Opgenorth T, Langenstroer P, Shapiro E, Lepor H . Binding and functional properties of endothelin receptor subtypes in the human prostate . Molecular Pharmacology . 45 . 2 . 306–11 . February 1994 . 8114678 .
• Yang H, Tabuchi H, Furuichi Y, Miyamoto C . Molecular characterization of the 5'-flanking region of human genomic ETA gene . Biochemical and Biophysical Research Communications . 190 . 2 . 332–9 . January 1993 . 8427579 . 10.1006/bbrc.1993.1052 .
• Elshourbagy NA, Korman DR, Wu HL, Sylvester DR, Lee JA, Nuthalaganti P, Bergsma DJ, Kumar CS, Nambi P . Molecular characterization and regulation of the human endothelin receptors . The Journal of Biological Chemistry . 268 . 6 . 3873–9 . February 1993 . 10.1016/S0021-9258(18)53554-7 . 8440682 . free .
• Miyamoto Y, Yoshimasa T, Arai H, Takaya K, Ogawa Y, Itoh H, Nakao K . Alternative RNA splicing of the human endothelin-A receptor generates multiple transcripts . The Biochemical Journal . 313 . 3 . 795–801 . February 1996 . 8611157 . 1216980 . 10.1042/bj3130795.
• Horstmeyer A, Cramer H, Sauer T, Müller-Esterl W, Schroeder C . Palmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modification . The Journal of Biological Chemistry . 271 . 34 . 20811–9 . August 1996 . 8702836 . 10.1074/jbc.271.34.20811 . free .
• Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ . Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity . The Journal of Biological Chemistry . 272 . 28 . 17734–43 . July 1997 . 9211925 . 10.1074/jbc.272.28.17734 . free .
• Bourgeois C, Robert B, Rebourcet R, Mondon F, Mignot TM, Duc-Goiran P, Ferré F . Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3 . The Journal of Clinical Endocrinology and Metabolism . 82 . 9 . 3116–23 . September 1997 . 10.1210/jcem.82.9.4209 . 9284755 . free .
• Mao XQ, Gao PS, Roberts MH, Enomoto T, Kawai M, Sasaki S, Shaldon SR, Coull P, Dake Y, Adra CN, Hagihara A, Shirakawa T, Hopkin JM . Variants of endothelin-1 and its receptors in atopic asthma . Biochemical and Biophysical Research Communications . 262 . 1 . 259–62 . August 1999 . 10448102 . 10.1006/bbrc.1999.1158 .
• Maggi M, Barni T, Fantoni G, Mancina R, Pupilli C, Luconi M, Crescioli C, Serio M, Vannelli GB . Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons . The Journal of Clinical Endocrinology and Metabolism . 85 . 4 . 1658–65 . April 2000 . 10.1210/jcem.85.4.6565 . 10770212 . 22812539 . free .
• Shraga-Levine Z, Sokolovsky M . Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific . Cellular and Molecular Neurobiology . 20 . 3 . 305–17 . June 2000 . 10789830 . 10.1023/A:1007010125316 . 21841332 .
• Lee HJ, Chun M, Kandror KV . Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling . The Journal of Biological Chemistry . 276 . 20 . 16597–600 . May 2001 . 11262386 . 10.1074/jbc.C000909200 . free .
• Paasche JD, Attramadal T, Sandberg C, Johansen HK, Attramadal H . Mechanisms of endothelin receptor subtype-specific targeting to distinct intracellular trafficking pathways . The Journal of Biological Chemistry . 276 . 36 . 34041–50 . September 2001 . 11382773 . 10.1074/jbc.M103243200 . free .
• Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ . Endothelin . Pharmacological Reviews . 68 . 2 . 357–418 . April 2016 . 26956245 . 10.1124/pr.115.011833 . 4815360.
• Han SG, Ko S, Lee WK, Jung ST, Yu YG . Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method . Scientific Reports . 7 . 1 . 7577 . August 2017 . 10.1038/s41598-017-08096-6. 28790412 . 5548930 . 2017NatSR...7.7577H .

Notes and References

1. Web site: Entrez Gene: EDNRA endothelin receptor type A.
2. Lee HJ, Chun M, Kandror KV . Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling . The Journal of Biological Chemistry . 276 . 20 . 16597–600 . May 2001 . 11262386 . 10.1074/jbc.C000909200 . free .