Endothelin-converting enzyme 1 explained
| Endothelin-converting enzyme 1 |
| Ec Number: | 3.4.24.71 |
| Cas Number: | 138238-81-0 |
Endothelin-converting enzyme 1 (endothelin-converting enzyme, ECE-1) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction
Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1
This metalloendopeptidase belongs to the peptidase family M13.
Notes and References
- Takahashi M, Matsushita Y, Iijima Y, Tanzawa K . Purification and characterization of endothelin-converting enzyme from rat lung . The Journal of Biological Chemistry . 268 . 28 . 21394–8 . October 1993 . 10.1016/S0021-9258(19)36936-4 . 8407980 . free .
- Shimada K, Takahashi M, Tanzawa K . Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells . The Journal of Biological Chemistry . 269 . 28 . 18275–8 . July 1994 . 10.1016/S0021-9258(17)32298-6 . 8034569 . free .
- Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D, Yanagisawa M . ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1 . Cell . 78 . 3 . 473–85 . August 1994 . 8062389 . 10.1016/0092-8674(94)90425-1 . 7872049 .
