Emily Bernstein Explained

Emily Bernstein
Workplaces:Mount Sinai College of Medicine
Alma Mater:State University of New York at Stony Brook
Thesis Title:Dicer, a novel RNase III, is required for RNA interference and development
Thesis Url:https://www.worldcat.org/oclc/
Thesis Year:2003
Doctoral Advisor:Gregory Hannon

Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference, epigenetics, and cancer, especially melanoma.

Education and career

Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. from Stony Brook University in 2003.[1] Following her Ph.D. she was a postdoctoral researcher at Rockefeller University where she worked with David Allis.[2] In 2008 she moved to Mount Sinai School of Medicine where, as of 2022, she is a professor in the department of oncology and dermatology.[3]

Research

Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzyme Dicer, its role in cell development in mice,[4] and RNA interference.[5] While a postdoctoral researcher she examined linkages between non-coding RNA and chromatin[6] [7] and DNA methylation.[8] Subsequently, she has worked on histones,[9] [10] gene silencing,[11] and tumor cell development.[12] [13] In 2022 her team discovered alterations to a gene which can lead to melanoma.[14] [15]

Selected publications

Awards and honors

In 2014 Bernstein received a young investigators award from the Pershing Square Foundation.[16]

External links

Notes and References

  1. Web site: 2022-05-15 . Speakers . 2022-05-15 . https://web.archive.org/web/20220515145545/https://wistar.org/speakers-0 . 15 May 2022 . dead.
  2. Web site: 2015-04-16 . Investigator Bernstein Laboratory . 2022-05-15 . Bernstein Laboratory .
  3. Web site: Emily Bernstein Mount Sinai - New York . 2022-05-15 . Mount Sinai Health System . en-US.
  4. Bernstein . Emily . Kim . Sang Yong . Carmell . Michelle A . Murchison . Elizabeth P . Alcorn . Heather . Li . Mamie Z . Mills . Alea A . Elledge . Stephen J . Anderson . Kathryn V . Hannon . Gregory J . 2003-11-01 . Dicer is essential for mouse development . Nature Genetics . en . 35 . 3 . 215–217 . 10.1038/ng1253 . 14528307 . 972721 . 1061-4036.
  5. Bernstein . Emily . Caudy . Amy A. . Hammond . Scott M. . Hannon . Gregory J. . 2001 . Role for a bidentate ribonuclease in the initiation step of RNA interference . Nature . en . 409 . 6818 . 363–366 . 10.1038/35053110 . 11201747 . 4371481 . 0028-0836.
  6. Bernstein . Emily . Allis . C. David . 2005-07-15 . RNA meets chromatin . Genes & Development . en . 19 . 14 . 1635–1655 . 10.1101/gad.1324305 . 16024654 . 0890-9369. free .
  7. Bernstein . Emily . Duncan . Elizabeth M. . Masui . Osamu . Gil . Jesus . Heard . Edith . Allis . C. David . 2006 . Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin . Molecular and Cellular Biology . en . 26 . 7 . 2560–2569 . 10.1128/MCB.26.7.2560-2569.2006 . 0270-7306 . 1430336 . 16537902.
  8. Ooi . Steen K. T. . Qiu . Chen . Bernstein . Emily . Li . Keqin . Jia . Da . Yang . Zhe . Erdjument-Bromage . Hediye . Tempst . Paul . Lin . Shau-Ping . Allis . C. David . Cheng . Xiaodong . 2007 . DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA . Nature . en . 448 . 7154 . 714–717 . 10.1038/nature05987 . 0028-0836 . 2650820 . 17687327. 2007Natur.448..714O .
  9. Gaspar-Maia . Alexandre . Qadeer . Zulekha A. . Hasson . Dan . Ratnakumar . Kajan . Adrian Leu . N. . Leroy . Gary . Liu . Shichong . Costanzi . Carl . Valle-Garcia . David . Schaniel . Christoph . Lemischka . Ihor . 2013-06-26 . MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency . Nature Communications . en . 4 . 1 . 1565 . 10.1038/ncomms2582 . 2041-1723 . 4055026 . 23463008. 2013NatCo...4.1565G .
  10. Vardabasso . Chiara . Hasson . Dan . Ratnakumar . Kajan . Chung . Chi-Yeh . Duarte . Luis F. . Bernstein . Emily . 2014 . Histone variants: emerging players in cancer biology . Cellular and Molecular Life Sciences . en . 71 . 3 . 379–404 . 10.1007/s00018-013-1343-z . 1420-682X . 4025945 . 23652611.
  11. Chicas . Agustin . Kapoor . Avnish . Wang . Xiaowo . Aksoy . Ozlem . Evertts . Adam G. . Zhang . Michael Q. . Garcia . Benjamin A. . Bernstein . Emily . Lowe . Scott W. . 2012-06-05 . H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence . Proceedings of the National Academy of Sciences . en . 109 . 23 . 8971–8976 . 10.1073/pnas.1119836109 . 0027-8424 . 3384172 . 22615382. 2012PNAS..109.8971C . free .
  12. Sosa . Maria Soledad . Parikh . Falguni . Maia . Alexandre Gaspar . Estrada . Yeriel . Bosch . Almudena . Bragado . Paloma . Ekpin . Esther . George . Ajish . Zheng . Yang . Lam . Hung-Ming . Morrissey . Colm . 2015 . NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes . Nature Communications . en . 6 . 1 . 6170 . 10.1038/ncomms7170 . 2041-1723 . 4313575 . 25636082. 2015NatCo...6.6170S .
  13. Strub . Thomas . Ghiraldini . Flavia G. . Carcamo . Saul . Li . Man . Wroblewska . Aleksandra . Singh . Rajendra . Goldberg . Matthew S. . Hasson . Dan . Wang . Zichen . Gallagher . Stuart J. . Hersey . Peter . 2018 . SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling . Nature Communications . en . 9 . 1 . 3440 . 10.1038/s41467-018-05966-z . 2041-1723 . 6109055 . 30143629. 2018NatCo...9.3440S .
  14. Web site: April 6, 2022 . Scientists discover gene mutation that signals aggressive melanoma . 2022-05-15 . ScienceDaily . en.
  15. Carcamo . Saul . Nguyen . Christie B. . Grossi . Elena . Filipescu . Dan . Alpsoy . Aktan . Dhiman . Alisha . Sun . Dan . Narang . Sonali . Imig . Jochen . Martin . Tiphaine C. . Parsons . Ramon . 2022-04-05 . Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma . Cell Reports . English . 39 . 1 . 110637 . 10.1016/j.celrep.2022.110637 . 2211-1247 . 9013128 . 35385731.
  16. News: Benson . Barbara . May 5, 2014 . Wall Street funds cancer-research up-and-comers . 30 . 22 . Crain's New York Business; New York . 18 . ProQuest.

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