| Elisabeth of Saxony | |
| Noble Family: | House of Wettin |
| Father: | August, Elector of Saxony |
| Mother: | Anna of Denmark |
| Spouse: | John Casimir of the Palatinate-Simmern |
| Issue: | Countess Palatine Dorothea of Simmern |
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| Birth Place: | Wolkenstein Castle in Wolkenstein |
| Death Place: | Heidelberg |
Elisabeth of Saxony (18 October 1552, at Wolkenstein Castle in Wolkenstein – 2 April 1590, in Heidelberg) was a Saxon princess, and Countess Palatine of Simmern by marriage to John Casimir of the Palatinate-Simmern.
Elisabeth was a daughter of the Elector August of Saxony (1526–1586) from his marriage to Anna (1532–1585), daughter of King Christian III of Denmark.
She married on 4 June 1570 in Heidelberg during the Diet of Speyer with Count Palatine John Casimir of Simmern (1543–1592). August opposed the policies of John Casimir, who was a Calvinist and friendly to France. With this marriage, August hoped to woo John Casimir over to the Lutheran side. However, he did not succeed. The Catholics in Germany regarded the marriage as a provocation against the Habsburg dynasty and an attempt to form a united Protestant front.
The Calvinist Johann Casimir tried to break the religious opposition of his Lutheran wife. In October 1585, she was arrested and accused of adultery and a murder plot against her husband. Even her brother, Elector Christian I, was convinced of her guilt. She converted to Calvinism while in captivity, and died shortly afterwards.
From her marriage with John Casimir, Elizabeth had the following children: