Chymotrypsin-C Explained

Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.^{[1] [2]}

Function

Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity.^[1]

Further reading

• Freeman TC, Davies R, Calam J . Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors. . Clin. Chim. Acta . 195 . 1–2 . 27–39 . 1990 . 2093478 . 10.1016/0009-8981(90)90191-T .
• Masson E, Chen JM, Scotet V . Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis . Hum. Genet. . 123 . 1 . 83–91 . 2008 . 18172691 . 10.1007/s00439-007-0459-3 . 20466442 . etal.
• Rosendahl J, Witt H, Szmola R . Chymotrypsin C (CTRC) alterations that diminish activity or secretion are associated with chronic pancreatitis . Nat. Genet. . 40 . 1 . 78–82 . 2008 . 18059268 . 2650829 . 10.1038/ng.2007.44 . etal.
• Kitahara K, Kawa S, Katsuyama Y . Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients . Dis. Markers . 25 . 3 . 175–80 . 2008 . 19096130 . 10.1155/2008/426764. etal. 3827802 . free .
• Stavridi ES, O'Malley K, Lukacs CM . Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis . Biochemistry . 35 . 33 . 10608–15 . 1996 . 8718849 . 10.1021/bi9605806 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Chang MC, Chang YT, Wei SC . Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan . Pancreatology . 9 . 3 . 287–92 . 2009 . 19407484 . 10.1159/000199437 . 25853177 . etal.
• Yoshino-Yasuda I, Kobayashi K, Akiyama M . Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene . J. Biochem. . 123 . 3 . 546–54 . 1998 . 9538241 . 10.1093/oxfordjournals.jbchem.a021971. etal.
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• Harris WR, Malencik DA, Johnson CM . Purification and characterization of catalytic fragments of phosphorylase kinase gamma subunit missing a calmodulin-binding domain . J. Biol. Chem. . 265 . 20 . 11740–5 . 1990 . 10.1016/S0021-9258(19)38460-1 . 2365696 . etal. free .
• Derikx MH, Szmola R, te Morsche RH . Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants . Eur J Gastroenterol Hepatol . 21 . 8 . 889–94 . 2009 . 19404200 . 10.1097/MEG.0b013e32832183cf . 22812634 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Szmola R . Sahin-Tóth M . Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: Identity with Rinderknecht's enzyme Y . Proc. Natl. Acad. Sci. U.S.A. . 104 . 27 . 11227–32 . 2007 . 17592142 . 2040881 . 10.1073/pnas.0703714104 . 2007PNAS..10411227S . free .
• Brecher AS, Yang MP . Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity . J. Investig. Med. . 46 . 4 . 146–52 . 1998 . 9635374 .

Notes and References

1. Web site: Entrez Gene: chymotrypsin C (caldecrin).
2. Tomomura A, Akiyama M, Itoh H, Yoshino I, Tomomura M, Nishii Y, Noikura T, Saheki T . Molecular cloning and expression of human caldecrin . FEBS Lett. . 386 . 1 . 26–8 . May 1996 . 8635596 . 10.1016/0014-5793(96)00377-8. free .