Idursulfase Explained

Idursulfase (brand name Elaprase), manufactured by Takeda, is a drug used to treat Hunter syndrome (also called MPS-II).^[1] It is a purified form of iduronate-2-sulfatase, a lysosomal enzyme, and is produced by recombinant DNA technology in a human cell line.

It is one of the most expensive drugs ever produced, costing US$567,412 per patient per year.^{[2] [3] [4]}

References

1. Garcia AR, DaCosta JM, Pan J, Muenzer J, Lamsa JC . Preclinical dose ranging studies for enzyme replacement therapy with idursulfase in a knock-out mouse model of MPS II . Mol. Genet. Metab. . 91 . 2 . 183–90 . 2007 . 17459751 . 10.1016/j.ymgme.2007.03.003.
2. News: Drug approved to treat rare but potentially deadly disease . 2011-04-29 . https://web.archive.org/web/20110224123252/http://www.mediadoctor.ca/content/article.jsp?intArticleID=293 . 2011-02-24 . dead .
3. https://www.forbes.com/2010/02/19/expensive-drugs-cost-business-healthcare-rare-diseases_print.html Health Care: The World's Most Expensive Drugs
4. http://www.marketwatch.com/story/1bn-here-we-come-martin-shkreli-told-turing-board-as-daraprim-buy-got-closer-2016-02-03?dist=countdown