| El Santuario | |
| Settlement Type: | Municipality & Town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | Antioquia Department |
| Subdivision Type2: | Subregion |
| Subdivision Name2: | Eastern |
| Leader Title: | Mayor |
| Leader Name: | Juan David Zuluaga Zuluaga (2020-2023) |
| Established Title: | Foundation |
| Established Date: | March 11, 1765 |
| Area Total Km2: | 83.45 |
| Area Urban Km2: | 2.02 |
| Population As Of: | 2018 census |
| Population Footnotes: | [1] |
| Population Total: | 35422 |
| Population Density Km2: | auto |
| Population Urban: | 24614 |
| Population Density Urban Km2: | auto |
| Coordinates: | 6.1375°N -75.2639°W |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
| Elevation M: | 2150 |
El Santuario is a town and municipality in the Antioquia Department, Colombia. It is part of the subregion of Eastern Antioquia. El Santuario was founded on 11 March 1765 by Captain Antonio Gómez de Castro. Its elevation is 2,150 meters above sea level, with an average temperature of 17 °C. The distance reference from Medellín city, the capital of Antioquia Department, is 57 km and it has a total area of 83.45 km². This town is well known for being the place where comedian Guillermo Zuluaga "Montecristo" and actor Crisanto Alonso Vargas "Vargasvil" were born. The more significant source of its economy is agriculture, mainly vegetables, beans, potatoes and legume cultivation.