| Efrosinia Doroshenko Єфросинія Дорошенко | |
| Birth Name: | Efrosinia Yanenko-Khmelnytska |
| Death Date: | 1684 |
| Death Place: | Yaropolchy |
| Occupation: | Former First Lady of Ukraine |
| Term Start1: | 1665 |
| Term End1: | 1669 |
| President1: | Petro Doroshenko |
| Predecessor1: | Daria Dolgorukova |
| Successor1: | Anastasia Ihnatovych |
| Spouse: | Petro Doroshenko |
Efrosinia Yanenko-Khmelnytsky (died 1684), was a Ukrainian Hetmana by marriage to Petro Doroshenko, Hetman of Zaporizhian Host (r. 1665–1676). She was an influential figure among the Ukrainian Cossacks. She is known for her alleged life style, as she was said to have several extramarital affairs, and also for a myth regarding her importance for the independence of Ukraine.