| Efren de la Cruz | |
| Fullname: | Efren Alberto de la Cruz Mieles |
| Birth Date: | 23 March 1989 |
| Birth Place: | Portoviejo, Ecuador |
| Position: | Midfielder |
| Youthyears1: | 2003 |
| Youthclubs1: | El Nacional |
| Youthyears2: | 2006 - |
| Youthclubs2: | LDU Quito |
| Years1: | 2008–2009 |
| Clubs1: | LDU Quito |
| Caps1: | 2 |
| Goals1: | 0 |
| Years2: | 2010 |
| Clubs2: | Deportivo Quito |
| Caps2: | 0 |
| Goals2: | 0 |
| Years3: | 2011 |
| Clubs3: | Águilas |
| Caps3: | 10 |
| Goals3: | 0 |
| Years4: | 2012 |
| Clubs4: | El Guayacán |
| Caps4: | 6 |
| Goals4: | 2 |
| Years5: | 2013–2014 |
| Clubs5: | Napoli |
| Caps5: | 13 |
| Goals5: | 0 |
| Club-Update: | April 27, 2014 |
Efren Alberto de la Cruz Mieles (born March 25, 1989, in Portoviejo) is an Ecuadorian footballer.