| Effia-Kwesimintsim Municipal District | |
| Settlement Type: | Municipal District |
| Pushpin Map: | Ghana |
| Pushpin Map Caption: | Location of Effia-Kwesimintsim Municipal District within Western |
| Subdivision Type: | Country |
| Subdivision Name: |  Ghana |
| Subdivision Type1: | Region |
| Subdivision Name1: | Western |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Kwesinmintsim |
| Leader Title: | Municipal Chief Executive |
| Area Total Km2: | 50.77 |
| Population As Of: | 2021[1] |
| Population Total: | 173,975 |
| Population Density Km2: | auto |
| Timezone: | GMT |
| Utc Offset: | +0 |
| Coordinates: | 4.9145°N -1.7876°W |
| Iso Code: | GH-WP-EK |
Effia-Kwesimintsim Municipal District is one of the fourteen districts in Western Region, Ghana. Originally it was formerly part of the then-larger Sekondi Takoradi Metropolitan District on 29 February 2008, until the western part of the district was split off to create Effia-Kwesimintsim Municipal District on 15 March 2018; thus the remaining part has been retained as Sekondi Takoradi Metropolitan District. The municipality is located in the southeast part of Western Region and has Kwesimintsim as its capital town.