| Edwin Santibáñez | |
| Fullname: | Edwin Santibáñez Noé |
| Height: | 1.70 m |
| Birth Date: | 1 February 1980 |
| Birth Place: | Torreón, Coahuila, Mexico |
| Currentclub: | León (women) (Assistant) |
| Years1: | 2002–2004 |
| Years2: | 2004–2005 |
| Years3: | 2005–2010 |
| Years4: | 2010–2013 |
| Caps1: | 70 |
| Caps2: | 12 |
| Caps3: | 150 |
| Caps4: | 32 |
| Goals1: | 7 |
| Goals2: | 1 |
| Goals3: | 7 |
| Goals4: | 2 |
| Manageryears1: | 2013–2014 |
| Managerclubs1: | León (Goalkeeper coach) |
| Manageryears2: | 2015 |
| Managerclubs2: | América (Goalkeeper coach) |
| Manageryears3: | 2015 |
| Managerclubs3: | Atlas (Assistant) |
| Manageryears4: | 2023– |
| Managerclubs4: | León (women) (Assistant) |
| Pcupdate: | 10 November 2012 |
Edwin Santibáñez (born 1 February 1980) is a Mexican retired footballer. He played for Club León of the Liga de Ascenso. In the Mexican draft of July 5, he decided to end his career as a player.
Santibáñez played for Mexico at the 1997 FIFA U-17 World Championship in Egypt.