| Edwin Edward Willis | |
| Office: | Member of the U.S. House of Representatives from Louisiana's 3rd district |
| Term Start: | January 3, 1949 |
| Term End: | January 3, 1969 |
| Preceded: | James R. Domengeaux |
| Succeeded: | Patrick T. Caffery |
| Office2: | Member of the Louisiana State Senate from Lafayette Parish |
| Term Start2: | 1948 |
| Term End2: | 1948 |
| Preceded2: | Two-member district: Edward P. Burguieres Cornelius P. Voorhies |
| Succeeded2: | Bernard Trappey |
| Occupation: | Attorney |
| Party: | Democratic |
| Birth Date: | 2 October 1904 |
| Birth Place: | Arnaudville, Louisiana, U.S. |
| Death Place: | St. Martinville, Louisiana, U.S. |
| Resting Place: | St. Michael's Cemetery in St. Martinville, Louisiana |
| Spouse: | Estelle Bulliard Willis |
| Children: | 1 |
| Alma Mater: | St. Martinville High School Loyola University New Orleans College of Law |
Edwin Edward Willis (October 2, 1904 - October 24, 1972) was an American politician and attorney from the U.S. state of Louisiana who was affiliated with the Long political faction. A Democrat, he served in the Louisiana State Senate during 1948 and in the United States House of Representatives from 1949 to 1969. Willis served on the U.S. House of Representatives' Un-American Activities Committee (HUAC).