Edward Johnson Wayne Explained
Sir Edward Johnson Wayne (3 June 1902 – 19 August 1990) was an English physician, biochemist, thyroidologist, and professor of medicine.[2]
Biography
Wayne attended Leeds Central High School from 1914 to 1920 and then matriculated at the University of Leeds, graduating there in 1923 BSc in chemistry and in 1924 MSc after working on organic chemistry. He then went to the University of Manchester to do research[2] under Hugh Stanley Raper[3] on the intermediary metabolism of the fatty acids. Wayne graduated there in 1925 with a PhD.[2]
He took classes in anatomy and physiology during a postdoctoral year of research at Manchester and then returned in 1926 to Leeds to study medicine, graduating MB, ChB in 1929.[2] From 1930 to 1931 he was a demonstrator in physiology at the University of Leeds.[1]
From 1931 to 1934 Wayne worked as an assistant under the cardiologist Thomas Lewis in the department of clinical research at University College Hospital, London. He qualified MRCP in 1932.[2] From 1934 to 1953 he was Professor of Pharmacology and Therapeutics at the University of Sheffield,[1] "establishing a reputation as a clinical scientist and as a talented director of research." He also became an associate physician to Sheffield Royal Infirmary. He was elected FRCP in 1937 and graduated MD in 1938. In 1953, as successor to Sir John William McNee, Wayne was appointed Regius Professor of the Practice of Medicine at Glasgow University. He held the professorship until his retirement as professor emeritus in 1967.[2] In 1956 he was elected a member of the Harveian Society of Edinburgh.[4]
He was the Bradshaw Lecturer in 1953 and the Lumleian Lecturer in 1959. He was elected FRCPE in 1955. He was knighted in 1964.[2]
In 1932 in Scarborough, North Yorkshire he married Honora Nancy Halloran. Upon his death in 1990 he was survived by his widow, a son, and a daughter.[1]
Wayne's diagnostic index
By using a statistical procedure partially based on discriminant analysis, James Crooks,[5] I. P. C. Murray, and Edward J. Wayne developed a clinical diagnostic index (sometimes called the "Wayne score") in thyrotoxicosis. The procedure allocates a positive or negative score to each clinical feature and provides a numerical estimate of the degree of severity of the disease.[6]
Older generations of endocrinologists were familiar with the use of Wayne's score and Billewicz's score[7] for clinical diagnoses of hyperthyroidism and hypothyroidism, respectively. Contemporary medical textbooks have discarded those two diagnostic scores as old-fashioned. However, various scoring and grading systems in clinical thyroidology might still have value.[8]
Selected publications
Articles
- The estimation of hippuric and phenaceturic acids in urine. Biochem J. 1928. 22. 1. 183–187. 1252104. Wayne. E. J.. 16743995. 10.1042/bj0220183.
- Painful Feet from the Physician's Point of View. Postgrad Med J. October 1943. 19. 215. 239–242. 2478026. Wayne. E. J.. 21313339. 10.1136/pgmj.19.215.239.
- with J. F. Goodwin and H. B. Stoner: The effect of adenosine triphosphate on the electrocardiogram of man and animals. Br Heart J. January 1949. 11. 1. 55–67. 503617. Wayne. E. J.. Goodwin. J. F.. Stoner. H. B.. 18113469. 10.1136/hrt.11.1.55.
- with John L. Emery, L. M. Rose, and Sheila M. Stewart: Procaine Penicillin with Aluminium Monostearate. Br Med J. 25 June 1949. 1. 4616. 1110–1112. 2050391. Emery. J. L.. Rose. L. M.. Stewart. S. M.. Wayne. E. J.. 18145953. 10.1136/bmj.1.4616.1110.
- with J. F. Goodwin and R. Steiner: Transposition of the aorta and pulmonary artery demonstrated by angiocardiography. Br Heart J. July 1949. 11. 3. 279–286. 479377. Goodwin. J. F.. Steiner. R.. Wayne. E. J.. 18145530. 10.1136/hrt.11.3.279.
- with J. Colquhoun and Joyce BurkeProcaine Penicillin with Aluminium Monostearate in Adults. Br Med J. 10 December 1949. 2. 4640. 1319–1322. 2052081. Wayne. E. J.. Colquhoun. J.. Burke. J.. 15407914. 10.1136/bmj.2.4640.1319.
- with Alastair G. Macgregor: Fluorescein test of circulation time in peripheral vascular disease. Br Heart J. January 1951. 13. 1. 80–88. 503677. MacGregor. A. G.. Wayne. E. J.. 14791888. 10.1136/hrt.13.1.80.
- with G. W. Blomfield, A. G. Macgregor, and H. Miller: Treatment of Thyrotoxicosis with Radioactive Iodine. Br Med J. 18 August 1951. 2. 4728. 373–381. 2069753. Blomfield. G. W.. MacGregor. A. G.. Miller. H.. Wayne. E. J.. 14858860. 10.1136/bmj.2.4728.373.
- Medical Relief of Pain. Br Med J. 29 September 1951. 2. 4734. 787–789. 2069831. Wayne. E. J.. 14869722. 10.1136/bmj.2.4734.787.
- Correct Dose of Digitalin. Br Med J. 6 October 1951. 2. 4735. 850. 2070026. Wayne. E. J.. 10.1136/bmj.2.4735.850-a.
- with E. K. Blackburn, Joyce Burke, and Cissie Roseman: Comparison of Liver Extract and Vitamin B12 in Maintenance Treatment of Pernicious Anaemia. Br Med J. 2 August 1952. 2. 4778. 245–248. 2020972. Blackburn. E. K.. Burke. J.. Roseman. C.. Wayne. E. J.. 14935383. 10.1136/bmj.2.4778.245.
- The Diagnosis of Thyrotoxicosis. Br Med J. 20 February 1954. 1. 4859. 411–419. 2084526. Wayne. E. J.. 13126528. 10.1136/bmj.1.4859.411. (Bradshaw Lecture)
- Treatment of Peripheral Vascular Disease in Old Age. Br Med J. 25 September 1954. 2. 4890. 718–720. 2079051. Wayne. E. J.. 13190238. 10.1136/bmj.2.4890.718.
- Peripheral circulation. Br Med J. 15 January 1955. 1. 4906. 151–152. 2061045. Wayne. E. J.. 10.1136/bmj.1.4906.151-b.
- Atherosclerosis. Br Med J. 31 December 1955. 2. 4956. 1605–1606. 1981747. Wayne. E. J.. 10.1136/bmj.2.4956.1605-b.
- with G. W. Blomfield, J. C. Jones, A. G. Macgregor, H. Miller, and R. S. Weetch: Treatment of Thyrotoxicosis with Radioactive Iodine. Br Med J. 19 November 1955. 2. 4950. 1223–1229. 1981295. Blomfield. G. W.. Jones. J. C.. MacGregor. A. G.. Miller. H.. Wayne. E. J.. Weetch. R. S.. 13269836. 10.1136/bmj.2.4950.1223.
- with A. G. Macgregor: Toxic Goitre. Br Med J. 31 December 1955. 2. 4956. 1618. 1981754. MacGregor. A. G.. Wayne. E. J.. 10.1136/bmj.2.4956.1618.
- with F. P. Muldowney and M. M. Bluhm: Red-cell Survival in Paroxysmal Nocturnal Haemoglobinuria. Br Med J. 30 November 1957. 2. 5056. 1277–1279. 1963168. Muldowney. F. P.. Bluhm. M. M.. Wayne. E. J.. 13479697. 10.1136/bmj.2.5056.1277.
- with Russell Fraser and Selwyn Taylor: Thyroid Association. Br Med J. 11 January 1958. 1. 5062. 103. 2027101. Fraser. R.. Taylor. S.. Wayne. E. J.. 10.1136/bmj.1.5062.103-e.
- with J. Crooks: Potassium Perchlorate Sensitivity. Br Med J. 10 January 1959. 1. 5114. 112–3. 1992184. Crooks. J.. Wayne. E. J.. 13608094. MURRAY IP. 10.1136/bmj.1.5114.112-a.
- Clinical and Metabolic Studies in Thyroid Disease—I. Br Med J. 2 January 1960. 1. 5165. 1–11. 1966357. Wayne. E. J.. 13843210. 10.1136/bmj.1.5165.1. (1st of 2 Lumleian Lectures)
- Clinical and Metabolic Studies in Thyroid Disease—II. Br Med J. 9 January 1960. 1. 5166. 78–90. 1966196. Wayne. E. J.. 13843211. 10.1136/bmj.1.5166.78. (2nd of 2 Lumleian Lectures)
- with James Crooks, W. Watson Buchanan, and E. MacDonald: Effect of Pretreatment with Methylthiouracil on Results of 131I Therapy. Br Med J. 16 January 1960. 1. 5167. 151–154. 1966292. Crooks. J.. Buchanan. W. W.. Wayne. E. J.. MacDonald. E.. 13812984. 10.1136/bmj.1.5167.151.
- with J. J. R. Duthie, R. H. Girdwood, Douglas Hubble, A. G. Macgregor, Andrew Wilson, and G. M. Wilson: "Imferom" and Cancer. Br Med J. 16 July 1960. 2. 5193. 234. 2097726. Duthie. J. J.. Girdwood. R. H.. Hubble. D.. MacGregor. A. G.. Wayne. E. J.. Wilson. A.. Wilson. G. M.. 10.1136/bmj.2.5193.234-a.
- with W. Watson Buchanan, W. D. Alexander, J. Crooks, D. A. Koutras, J. R. Anderson, and R. B. Goudie: Association of Thyrotoxicosis and Auto-immune Thyroiditis. Br Med J. 25 March 1961. 1. 5229. 843–847. 1953621. Buchanan. W. W.. Alexander. W. D.. Crooks. J.. Koutras. D. A.. Wayne. E. J.. Anderson. J. R.. Goudie. R. B.. 20789100. 10.1136/bmj.1.5229.843.
- with William D. Alexander, D. A. Koutras, J. Crooks, W. W. Buchanan, E. M. MacDonald, and M. H. Richmond: Quantitative studies of iodine metabolism in thyroid disease. QJM: An International Journal of Medicine. 31. 3. 1962. 281–305. 10.1.1.1015.1080.
- Alcohol and Road Accidents. Br Med J. 7 December 1963. 2. 5370. 1467. 1873518. Wayne. E. J.. 14063057. 10.1136/bmj.2.5370.1467.
Books
- with Demetrios A Koutras and William De Witt Alexander: Book: Clinical aspects of iodine metabolism. 1964. Oxford. Blackwell Scientific Publications.
References
- Br Med J. Obituary. Sir Edward Wayne, MSC, PHD FRCP, FRCPED, FRCPGLAS. 27 September 1958. 301. 6752. 604–605. 10.1136/bmj.301.6752.604. 220181194.
- Web site: Edward Johnson (Sir) Wayne. Munk's Roll, Volume IX, Lives of the Fellows, Royal College of Physicians.
- Web site: Hugh Stanley Raper. Munk's Roll, Volume V, Lives of the Fellows, Royal College of Physicians.
- Book: Minute Books of the Harveian Society. Library of the Royal College of Physicians of Edinburgh.
- Web site: James Crooks. Munk's Roll, Volume VII, Lives of the Fellows, Royal College of Physicians.
- Crooks, J.. Murray, I. P. C.. Wayne, E. J.. 1959. Statistical methods applied to the clinical diagnosis of thyrotoxicosis. QJM: An International Journal of Medicine. 28. 2. 211–234. 13658351 .
- Billewicz WZ. Chapman RS. Crooks J. Day ME. Gossage J. Wayne E. Young JA. Statistical methods applied to the diagnosis of hypothyroidism. QJM: An International Journal of Medicine. 38. 2. 1969. 255–266. 10.1093/oxfordjournals.qjmed.a067179. 4181088.
- Indian J Endocrinol Metab. July 2011. 15(Suppl2). 6. S89–S94. 10.4103/2230-8210.83332. 21966660. 3169861. Clinical scoring scales in thyroidology: A compendium. Kalra, S.. Khandelwal, S. K.. Goyal, A. . free .
External links