Eduardo Arzt Explained

Eduardo Arzt
Birth Date:22 February 1953
Birth Place:Buenos Aires, Argentina
Field:Molecular Biology
Work Institution:CONICET, Max Planck Society, UBA
Prizes:Guggenheim Fellowship, Houssay award, Bunge y Born award, Konex award

Eduardo Arzt (born February 22, 1953) is an Argentine molecular biologist, Master in Experimental Biology, Doctor (Ph.D) from the Faculty of Pharmacy and Biochemistry (University of Buenos Aires). Currently, he is a senior researcher at CONICET, distinguished professor of the Faculty of Natural Sciences of the University of Buenos Aires, External Scientific Member of the Max Planck Society (Germany) and director of the Biomedicine Research Institute of Buenos Aires[1] – CONICET – Partner Institute of the Max Planck Society.

Contribution and recognition

His scientific contributions stand him out as an internationally recognized personality in the field of molecular neuroendocrinology. His laboratory contributed to the discovery of new genes and pathways involved in the physiological adaptation to homeostasis in response to stress,[2] [3] hypoxia (lack of cellular oxygen),[4] [5] physiopathological processes (pituitary tumors),[6] [7] [8] [9] [10] [11] [12] [13] [14] and to the discovery of new targets for pharmacological treatments.[15] [16] [17] [18]

He is known not only for his findings, which are an example of research in biomedicine, transferring results from basic molecular biology to pharmacological applications,[19] [20] [21] but also for his vast institutional achievements for Argentine and Latin-American science,[22] including an active and important role in the development and realization of the project of the Polo Científico Tecnológico[23] and the creation of the Biomedicine Research Institute of Buenos Aires[24] [25] – CONICET – Partner Institute of the Max Planck Society. He has received, for its ongoing work, both prestigious Argentine (Bunge and Born Award, Houssay Award) and International (Guggenheim Fellowship, External Scientific Member of the Max Planck Society, Order of Merit of the Federal Republic of Germany, Berthold Medal, TWAS Prize)[25] [26] awards and distinctions.

Bibliographic review / career

In 1970 he graduated from the Colegio Nacional de Buenos Aires, Argentina. The following year, he enrolled at the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires, and graduated in 1978.

In 1981 he began a Masters in Experimental Biology at the Universidad Autonoma Metropolitana, Mexico, and his Master's Thesis was on transportation models in biological membranes (1984).

From 1985 to 1988 at the UBA Faculty of Pharmacy and Biochemistry, he conducted his Ph.D. in cellular mechanisms involved in immune-neuroendocrine pathways, at the Institute for Medical Research A. Lanari, of the Faculty of Medicine (UBA).

In 1989 he joined the Scientific Researcher Career of CONICET, Argentina, where he is now a Senior Researcher.[27]

In 1995 he obtained the position of Professor in Molecular and Cellular Biology, Faculty of Natural Sciences (UBA).

In 1997 he participated as co-Founder and Director of the Laboratorio de Fisiología y Biología Molecular (LFBM-FCEN-UBA) [Laboratory of Physiology and Molecular Biology].

In 2005 he was appointed External Scientific Member of the Max Planck Society.[28] [29]

In 2007 he participated in the agreement for the establishment of the Biomedicine Research Institute of Buenos Aires – CONICET – Partner Institute of the Max Planck Society (IBioBA), whose construction was completed in 2012 at the Polo Científico y Tecnológico.[30]

Awards and distinctions

Notes and References

  1. http://ibioba-conicet.gov.ar/index_i.php Biomedicine Research Institute of Buenos Aires - CONICET - MPSP
  2. Refojo D, Echenique C, Müller MB . Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas . Proceedings of the National Academy of Sciences of the United States of America . 102 . 17 . 6183–8 . April 2005 . 15833812 . 1087957 . 10.1073/pnas.0502070102. 2005PNAS..102.6183R . etal. free .
  3. Arzt E, Holsboer F . CRF signaling: molecular specificity for drug targeting in the CNS . Trends in Pharmacological Sciences . 27 . 10 . 531–8 . October 2006 . 16935354 . 10.1016/j.tips.2006.08.007.
  4. Druker J, Liberman AC, Antunica-Noguerol M . RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity . Molecular and Cellular Biology . 33 . 11 . 2116–27 . June 2013 . 23508108 . 3648064 . 10.1128/MCB.01470-12. etal.
  5. Carbia-Nagashima A, Gerez J, Perez-Castro C . RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia . Cell . 131 . 2 . 309–23 . October 2007 . 17956732 . 10.1016/j.cell.2007.07.044. 12486303 . etal. 20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima . free .
  6. Arzt E, Stelzer G, Renner U, Lange M, Müller OA, Stalla GK . Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures . The Journal of Clinical Investigation . 90 . 5 . 1944–51 . November 1992 . 1331177 . 443256 . 10.1172/JCI116072.
  7. Arzt E, Buric R, Stelzer G . Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6 . Endocrinology . 132 . 1 . 459–67 . January 1993 . 8419142 . 10.1210/endo.132.1.8419142. etal.
  8. Arzt E, Pereda MP, Castro CP, Pagotto U, Renner U, Stalla GK . Pathophysiological role of the cytokine network in the anterior pituitary gland . Frontiers in Neuroendocrinology . 20 . 1 . 71–95 . January 1999 . 9882537 . 10.1006/frne.1998.0176. 42782633 .
  9. Arzt E . gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways . The Journal of Clinical Investigation . 108 . 12 . 1729–33 . December 2001 . 11748253 . 209477 . 10.1172/JCI14660.
  10. Giacomini D, Páez-Pereda M, Stalla J, Stalla GK, Arzt E . Molecular interaction of BMP-4, TGF-beta, and estrogens in lactotrophs: impact on the PRL promoter . Molecular Endocrinology . 23 . 7 . 1102–14 . July 2009 . 19342445 . 5419174 . 10.1210/me.2008-0425.
  11. Perez-Castro C, Renner U, Haedo MR, Stalla GK, Arzt E . 73834 . Cellular and molecular specificity of pituitary gland physiology . Physiological Reviews . 92 . 1 . 1–38 . January 2012 . 22298650 . 10.1152/physrev.00003.2011. 11336/68927 . free .
  12. Paez-Pereda M, Giacomini D, Refojo D . Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk . Proceedings of the National Academy of Sciences of the United States of America . 100 . 3 . 1034–9 . February 2003 . 12552124 . 298721 . 10.1073/pnas.0237312100. 2003PNAS..100.1034P . etal. free .
  13. Arzt E, Chesnokova V, Stalla GK, Melmed S . Pituitary adenoma growth: a model for cellular senescence and cytokine action . Cell Cycle . 8 . 5 . 677–8 . March 2009 . 19223763 . 2710531 . 10.4161/cc.8.5.8065.
  14. Antunica-Noguerol. M. Budziñski. M L. Druker. J. Gassen. N C. Sokn. M C. Senin. S. Aprile-Garcia. F. Holsboer. F. Rein. T. 2016-05-13. The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51. Cell Death and Differentiation. en. 23. 10. 1579–1591. 10.1038/cdd.2016.44. 27177020. 5041187. 1476-5403.
  15. Giacomini D, Páez-Pereda M, Theodoropoulou M . Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action . Endocrinology . 147 . 1 . 247–56 . January 2006 . 16195406 . 10.1210/en.2005-0958. etal. free . 11336/44649 . free .
  16. Castillo V, Giacomini D, Páez-Pereda M . Retinoic acid as a novel medical therapy for Cushing's disease in dogs . Endocrinology . 147 . 9 . 4438–44 . September 2006 . 16740975 . 10.1210/en.2006-0414. etal. free . 11336/44644 . free .
  17. Páez-Pereda . Marcelo . Arzt . Eduardo . Stalla . Günter K . 2002 . Cushing's syndrome: Drug targets and therapeutic options . Expert Opinion on Therapeutic Patents . 12 . 10 . 1537–46 . 10.1517/13543776.12.10.1537. 71327660 .
  18. Gerez. J. Tedesco. L. Bonfiglio. J J. Fuertes. M. Barontini. M. Silberstein. S. Wu. Y. Renner. U. Páez-Pereda. M. 2014-12-15. RSUME inhibits VHL and regulates its tumor suppressor function. Oncogene. en. 34. 37. 4855–4866. 10.1038/onc.2014.407. 25500545. 1476-5594. free. 11336/31656. free.
  19. http://www.lanacion.com.ar/nota.asp?nota_id=954587 Descubren un gen maestro para entender la maquinaria celular
  20. http://www.clarin.com/diario/2007/10/19/sociedad/s-05401.htm Científicos argentinos hallan un gen maestro para luchar contra el cáncer
  21. http://www.lanacion.com.ar/nota.asp?nota_id=848947 Prueban con éxito una terapia para la enfermedad de Cushing
  22. Arzt E . Collaboration: Biomedical network in South America . Nature . 491 . 7424 . 333 . November 2012 . 23151571 . 10.1038/491333d. 2012Natur.491..333A . free . 11336/67883 . free .
  23. http://blogs.dw-world.de/de-tierra-del-fuego-a-tijuana/agentina/1.8473.html Ciencia entre Palermo Soho y Palermo Hollywood
  24. http://www.lanacion.com.ar/1530390-primer-mundo-en-pleno-palermo-como-es-el-nuevo-instituto-max-planck Primer Mundo, en Palermo: el imponente Instituto Max Planck
  25. http://www.alemaniaparati.diplo.de/Vertretung/mexiko-dz/es/03-PoliticaExterior/Lazos/DMagazineMaxPlanckenArgentina.html Centro Alemán de Información para Latinoamérica y España
  26. http://www.pagina12.com.ar/diario/sociedad/3-172615-2011-07-20.html Orden del Mérito
  27. Web site: Comunicación Conicet. www.conicet.gov.ar. es-ES. 2017-11-17.
  28. http://www.mpipsykl.mpg.de/en/people/arzt_e.shtml Max Planck Institute Psychiatry Munich
  29. http://www.lanacion.com.ar/nota.asp?nota_id=728571 Importante distinción a dos científicos argentinos
  30. http://www.polo.mincyt.gob.ar/ Polo Científico Tecnológico
  31. http://www.gf.org/fellows/487-eduardo-arzt John Simon Guggenheim Memorial Foundation
  32. http://www.fundacionbyb.org/ing_investigacion_cientifica_premio_fbyb_2008.asp Fundación Bunge y Born
  33. http://www.lanacion.com.ar/nota.asp?nota_id=1014919 Premio Bunge y Born a dos investigadores del CONICET
  34. http://www.clarin.com/diario/2008/08/13/sociedad/s-01736465.htm Premio Bunge y Born para un prestigioso investigador
  35. http://www.fundacionkonex.org/b4552-eduardo_arzt Fundación Konex
  36. Web site: Prizes and Awards . 2016 . The World Academy of Sciences.
  37. Web site: Eduardo Arzt awarded the Berthold Medal. www.psych.mpg.de. 2017-11-17.

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