| Edgardo Orzusa | |
| Fullname: | Edgardo Daniel Orzusa Cáceres |
| Birth Date: | 22 June 1990 |
| Birth Place: | Paraguarí, Paraguay |
| Position: | Midfielder |
| Currentclub: | Olimpia |
| Clubnumber: | 22 |
| Years1: | 2011–2015 |
| Clubs1: | Sol de América |
| Caps1: | 181 |
| Goals1: | 9 |
| Years2: | 2016–2021 |
| Clubs2: | Nacional |
| Caps2: | 146 |
| Goals2: | 9 |
| Years3: | 2018–2019 |
| Clubs3: | → Chapecoense (loan) |
| Caps3: | 9 |
| Goals3: | 0 |
| Years4: | 2021–2022 |
| Clubs4: | Olimpia |
| Caps4: | 17 |
| Goals4: | 0 |
| Years5: | 2023–2024 |
| Clubs5: | Nacional |
| Caps5: | 44 |
| Goals5: | 0 |
| Years6: | 2024– |
| Clubs6: | Sportivo Trinidense |
| Caps6: | 5 |
| Goals6: | 0 |
| Nationalyears1: | 2012 |
| Nationalteam1: | Paraguay |
| Nationalcaps1: | 2 |
| Nationalgoals1: | 0 |
| Club-Update: | 21 September 2024 |
Edgardo Daniel Orzusa Cáceres (born 22 June 1990) is a Paraguayan professional footballer who plays as a midfielder for Sportivo Trinidense.
Born in Paraguarí, Orzuza has played club football for Sol de América and Club Nacional.
He made his international debut for Paraguay in 2012.