EcpR1 sRNA explained

EcpR1 (elongated cell phenotype RNA1) is a trans-encoded small non-coding RNA in the plant-symbiotic Sinorhizobium meliloti, previously named SmelC291, SmrC10, or Sra33.[1] [2] [3] According to its overproduction phenotype it was renamed Elongated Cell Phenotype RNA1.[4] Induced by stress, EcpR1 negatively regulates cell cycle master regulatory genes dnaA and gcrA at post-transcriptional level by base pairing between its strongly conserved GC-rich loop and the target mRNAs. It is suggested that EcpR1 connects stress adaptation and cell cycle progression.

See also

Notes and References

  1. Schlüter JP, Reinkensmeier J, Daschkey S, Evguenieva-Hackenberg E, Janssen S, Jänicke S, Becker JD, Giegerich R, Becker A . A genome-wide survey of sRNAs in the symbiotic nitrogen-fixing alpha-proteobacterium Sinorhizobium meliloti . BMC Genomics . 11 . 245 . April 2010 . 20398411 . 2873474 . 10.1186/1471-2164-11-245 . free .
  2. Reinkensmeier J, Schlüter JP, Giegerich R, Becker A . Conservation and Occurrence of Trans-Encoded sRNAs in the Rhizobiales . Genes . 2 . 4 . 925–956 . November 2011 . 24710299 . 3927594 . 10.3390/genes2040925 . free .
  3. del Val C, Rivas E, Torres-Quesada O, Toro N, Jiménez-Zurdo JI . Identification of differentially expressed small non-coding RNAs in the legume endosymbiont Sinorhizobium meliloti by comparative genomics . Molecular Microbiology . 66 . 5 . 1080–1091 . December 2007 . 17971083 . 2780559 . 10.1111/j.1365-2958.2007.05978.x .
  4. Robledo M, Frage B, Wright PR, Becker A . A stress-induced small RNA modulates alpha-rhizobial cell cycle progression . PLOS Genetics . 11 . 4 . e1005153 . April 2015 . 25923724 . 4414408 . 10.1371/journal.pgen.1005153 . free .

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