Echinopsidine Explained

Echinopsidine (Adepren) is an antidepressant that was under development in Bulgaria for the treatment of depression.^{[1] [2]} It increases serotonin, norepinephrine, and dopamine levels in the brain and is believed to act as a monoamine oxidase inhibitor (MAOI).^{[3] [4] [5]} Echinopsidine is found naturally in Echinops echinatus along with the related alkaloids echinopsine and echinozolinone.^[6]

See also

• Monoamine oxidase inhibitor

Notes and References

1. Guliamov MG . [Experience with the use of new Bulgarian psychotropic drugs] . ru . Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova . 82 . 11 . 115–122 . 1982 . 6758442 .
2. Guliamov MG . [Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit] . ru . Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova . 86 . 4 . 582–587 . 1986 . 3716711 .
3. Tiutiulkova N, Gorancheva I . [Effect of adepren on the cerebral concentration of serotonin] . bg . Eksperimentalna Meditsina I Morfologiia . 17 . 2 . 83–85 . 1978 . 658004 .
4. Stefanova D, Tiutiulkova N, Nikolova M . [Effect of adepren on the behavior and brain catecholamines of rats in an open field setup] . bg . Eksperimentalna Meditsina I Morfologiia . 15 . 1 . 42–46 . 1976 . 1269462 .
5. Tiutiulkova NI, Gorancheva I . [Excretion of dopamine, noradrenaline, adrenaline, vanilmandelic acid and 5-hydroxyindoleacetic acid in the urine of volunteers treated with adepren] . bg . Eksperimentalna Meditsina I Morfologiia . 14 . 4 . 187–189 . 1975 . 1222713 .
6. Book: Khare CP . Echinops echinatus Roxb. . Indian Medicinal Plants An Illustrated Dictionary . Springer-Verlag Berlin Heidelberg . 2007 . 978-0-387-70637-5 . https://books.google.com/books?id=gMwLwbUwtfkC&q=Echinopsidine&pg=PA230.