East Second Street Commercial Historic District (Winona, Minnesota) should not be confused with East Second Street Commercial Historic District (Hastings, Minnesota).
| East Second Street Commercial Historic District | |
| Nrhp Type: | hd |
| Nocat: | yes |
| Coordinates: | 44.0533°N -91.6353°W |
| Location: | 66–78 Center, 54–78 East 2nd, and 67–71 Lafayette Streets, Winona, Minnesota |
| Area: | 3acres |
| Built: | 1863–1915 |
| Architecture: | Gothic Revival, Italianate |
| Refnum: | 90002198 |
| Designated Nrhp Type: | January 25, 1991 |
The East Second Street Commercial Historic District is a small historic district in Winona, Minnesota, United States. It comprises 14 contributing properties mostly built in the late 1860s.[1] The district was listed on the National Register of Historic Places in 1991 for its state-level significance in the themes of architecture and commerce.[2] It was nominated for being one of the few surviving remnants of the original business district of a Minnesota river town, and for being a symbol of Winona's swift growth as a lumber and grain trade center.