| East Branch Piscataquis River | |
| Mouth Location: | Piscataquis River |
| Mouth Coordinates: | 45.284°N -69.5919°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Progression: | Piscataquis River – Penobscot River |
The East Branch Piscataquis River is a tributary of the Piscataquis River in Piscataquis County, Maine. From its source in Little Squaw (Maine Township 3, Range 5, BKP EKR), it runs south [1] to its confluence with the West Branch Piscataquis River in Blanchard to form the Piscataquis.
The Appalachian Trail crosses the East Branch just upstream from its joining with the West Branch.