Early versus Late Intervention Trial with Estradiol explained

The Early versus Late Intervention Trial with Estradiol (ELITE) was a large randomized controlled trial that assessed the timing hypothesis that menopausal hormone therapy in early but not late menopause would improve cardiovascular outcomes.[1] [2]

Notes and References

  1. Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW . Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis . Menopause . 22 . 4 . 391–401 . April 2015 . 25380275 . 4376597 . 10.1097/GME.0000000000000343 .
  2. Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed JT, Sontakke SP . Sex differences in the vascular function and related mechanisms: role of 17β-estradiol . Am. J. Physiol. Heart Circ. Physiol. . 315 . 6 . H1499–H1518 . December 2018 . 30192631 . 10.1152/ajpheart.00194.2018 . free .

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