EZH1 explained

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.^{[1] [2]}

Function

In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.^[3] EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency.^[4]

Further reading

• Rommens JM, Durocher F, McArthur J . Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. . Genomics . 28 . 3 . 530–42 . 1996 . 7490091 . 10.1006/geno.1995.1185 . etal.
• Brody LC, Abel KJ, Castilla LH . Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17. . Genomics . 25 . 1 . 238–47 . 1995 . 7774924 . 10.1016/0888-7543(95)80131-5 . etal. free .
• Osborne-Lawrence S, Welcsh PL, Spillman M . Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21. . Genomics . 25 . 1 . 248–55 . 1995 . 7774925 . 10.1016/0888-7543(95)80132-6 . etal.
• Friedman LS, Ostermeyer EA, Lynch ED . 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. . Genomics . 25 . 1 . 256–63 . 1995 . 7774926 . 10.1016/0888-7543(95)80133-7 . etal. free .
• Nagase T, Ishikawa K, Nakajima D . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . etal. free .
• Ogawa M, Hiraoka Y, Taniguchi K, Aiso S . Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2. . Biochim. Biophys. Acta . 1395 . 2 . 151–8 . 1998 . 9473645 . 10.1016/s0167-4781(97)00156-5.
• Jones CA, Ng J, Peterson AJ . The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression. . Mol. Cell. Biol. . 18 . 5 . 2825–34 . 1998 . 9566901 . 10.1128/mcb.18.5.2825. 110661 . etal.
• van Lohuizen M, Tijms M, Voncken JW . Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. . Mol. Cell. Biol. . 18 . 6 . 3572–9 . 1998 . 9584197 . 10.1128/MCB.18.6.3572. 108938 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL . Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1 . Genomics . 37 . 2 . 161–71 . Feb 1997 . 8921387 . 10.1006/geno.1996.0537 . free .
2. Web site: Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila).
3. Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E . EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. . Genes Dev. . 25 . 5 . 485–98 . Mar 2011 . 21317239 . 3049289. 10.1101/gad.2019811.
4. Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH . EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. . Mol Cell . 32 . 4 . 491–502 . Nov 2008 . 19026780 . 2630502. 10.1016/j.molcel.2008.10.016.