Exosome component 9 explained

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which (sometimes called RRP45 or PM/Scl-75) is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.^[1]

Further reading

• Alderuccio F, Chan EK, Tan EM . Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex . J. Exp. Med. . 173 . 4 . 941–52 . 1991 . 2007859 . 10.1084/jem.173.4.941 . 2190817 .
• Allmang C . The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases . Genes Dev. . 13 . 16 . 2148–58 . 1999 . 10465791 . 10.1101/gad.13.16.2148 . 316947 . vanc. Petfalski E . Podtelejnikov A . 3 . Mann . M. . Tollervey . D. . Mitchell . P. .
• Brouwer R . Three novel components of the human exosome . J. Biol. Chem. . 276 . 9 . 6177–84 . 2001 . 11110791 . 10.1074/jbc.M007603200 . vanc. Allmang C . Raijmakers R . 3 . Van Aarssen . Y . Egberts . WV . Petfalski . E . Van Venrooij . WJ . Tollervey . D . Pruijn . GJ . free . 20.500.11820/a03680a4-cf3a-4827-805c-447483ff4b9f . free .
• Chen CY . AU binding proteins recruit the exosome to degrade ARE-containing mRNAs . Cell . 107 . 4 . 451–64 . 2002 . 11719186 . 10.1016/S0092-8674(01)00578-5 . vanc. Gherzi R . Ong SE . 3 . Chan . Edward L. . Raijmakers . Reinout . Pruijn . Ger J.M. . Stoecklin . Georg . Moroni . Christoph . Mann . Matthias . 14817671 . free .
• Mukherjee D . The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements . EMBO J. . 21 . 1–2 . 165–74 . 2002 . 11782436 . 10.1093/emboj/21.1.165 . 125812 . vanc. Gao M . O'Connor JP . 3 . Raijmakers . R . Pruijn . G . Lutz . CS . Wilusz . J .
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ . Protein-protein interactions of hCsl4p with other human exosome subunits . J. Mol. Biol. . 315 . 4 . 809–18 . 2002 . 11812149 . 10.1006/jmbi.2001.5265 . 2066/261980 . free .
• Brouwer R . Autoantibodies directed to novel components of the PM/Scl complex, the human exosome . Arthritis Res. . 4 . 2 . 134–8 . 2002 . 11879549 . 10.1186/ar389 . 83843 . vanc. Vree Egberts WT . Hengstman GJ . 3 . Raijmakers . Reinout . Van Engelen . Baziel GM . Peter Seelig . Hans . Renz . Manfred . Mierau . Rudolf . Genth . Ekkehard . free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring . J. Mol. Biol. . 323 . 4 . 653–63 . 2002 . 12419256 . 10.1016/S0022-2836(02)00947-6 . 2066/186665 . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus . J. Biol. Chem. . 278 . 33 . 30698–704 . 2003 . 12788944 . 10.1074/jbc.M302488200 . free . 2066/186428 . free .
• Lehner B . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . vanc. Semple JI . Brown SE . 3 . Counsell . Damian . Campbell . R.Duncan . Sanderson . Christopher M .
• Raijmakers R . PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome . Arthritis Rheum. . 50 . 2 . 565–9 . 2004 . 14872500 . 10.1002/art.20056 . vanc. Renz M . Wiemann C . 3 . Egberts . Wilma Vree . Seelig . Hans Peter . Van Venrooij . Walther J. . Pruijn . Ger J. M. .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . vanc. Lam YW . Leung AK . 3 . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Tsang HT . A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex . Genomics . 88 . 3 . 333–46 . 2006 . 16730941 . 10.1016/j.ygeno.2006.04.003 . vanc. Connell JW . Brown SE . 3 . Thompson . Amanda . Reid . Evan . Sanderson . Christopher M. .
• Olsen JV . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . vanc. Blagoev B . Gnad F . 3 . Macek . Boris . Kumar . Chanchal . Mortensen . Peter . Mann . Matthias . 7827573 . free.
• van Dijk EL, Schilders G, Pruijn GJ . Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways . RNA . 13 . 7 . 1027–35 . 2007 . 17545563 . 10.1261/rna.575107 . 1894934 .

Notes and References

1. Web site: Entrez Gene: EXOSC9 exosome component 9.