Exosome component 4 explained

Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.^[1]

Interactions

Exosome component 4 has been shown to interact with Exosome component 2.^[2]

Further reading

• Allmang C, Petfalski E, Podtelejnikov A . The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. . Genes Dev. . 13 . 16 . 2148–58 . 1999 . 10465791 . 316947 . 10.1101/gad.13.16.2148. etal.
• Brouwer R, Allmang C, Raijmakers R . Three novel components of the human exosome. . J. Biol. Chem. . 276 . 9 . 6177–84 . 2001 . 11110791 . 10.1074/jbc.M007603200 . etal. free . 2066/186951 . free .
• Chen CY, Gherzi R, Ong SE . AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. . Cell . 107 . 4 . 451–64 . 2002 . 11719186 . 10.1016/S0092-8674(01)00578-5. 14817671 . etal. free .
• Andersen JS, Lyon CE, Fox AH . Directed proteomic analysis of the human nucleolus. . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9. 14132033 . etal. free . 2002CBio...12....1A .
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ . Protein-protein interactions of hCsl4p with other human exosome subunits. . J. Mol. Biol. . 315 . 4 . 809–18 . 2002 . 11812149 . 10.1006/jmbi.2001.5265 . 2066/261980 . free .
• Brouwer R, Vree Egberts WT, Hengstman GJ . Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. . Arthritis Res. . 4 . 2 . 134–8 . 2002 . 11879549 . 83843 . 10.1186/ar389. etal . free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. . J. Mol. Biol. . 323 . 4 . 653–63 . 2002 . 12419256 . 10.1016/S0022-2836(02)00947-6. 2066/186665 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. . J. Biol. Chem. . 278 . 33 . 30698–704 . 2003 . 12788944 . 10.1074/jbc.M302488200 . free . 2066/186428 . free .
• Lejeune F, Li X, Maquat LE . Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. . Mol. Cell . 12 . 3 . 675–87 . 2003 . 14527413 . 10.1016/S1097-2765(03)00349-6. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Andersen JS, Lam YW, Leung AK . Nucleolar proteome dynamics. . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Oh JH, Yang JO, Hahn Y . Transcriptome analysis of human gastric cancer. . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 . etal.
• van Dijk EL, Schilders G, Pruijn GJ . Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. . RNA . 13 . 7 . 1027–35 . 2007 . 17545563 . 10.1261/rna.575107 . 1894934.

Notes and References

1. Web site: Entrez Gene: EXOSC4 exosome component 4.
2. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring . J. Mol. Biol. . 323 . 4 . 653–63 . 2002 . 12419256 . 10.1016/S0022-2836(02)00947-6 . 2066/186665 . free .