Exosome component 10 explained

Exosome component 10, also known as EXOSC10, is a human gene, the protein product of which (sometimes called PM/Scl-100) is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.^[1]

Further reading

• Blüthner M, Bautz FA . Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein. . J. Exp. Med. . 176 . 4 . 973–80 . 1992 . 1383382 . 2119404 . 10.1084/jem.176.4.973 .
• Ge Q, Frank MB, O'Brien C, Targoff IN . Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen. . J. Clin. Invest. . 90 . 2 . 559–70 . 1992 . 1644924 . 443135 . 10.1172/JCI115895.
• Allmang C, Petfalski E, Podtelejnikov A . The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases. . Genes Dev. . 13 . 16 . 2148–58 . 1999 . 10465791 . 316947 . 10.1101/gad.13.16.2148. etal.
• Brouwer R, Allmang C, Raijmakers R . Three novel components of the human exosome. . J. Biol. Chem. . 276 . 9 . 6177–84 . 2001 . 11110791 . 10.1074/jbc.M007603200 . etal. free . 20.500.11820/a03680a4-cf3a-4827-805c-447483ff4b9f . free .
• Stover C, Endo Y, Takahashi M . The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3. . Genes Immun. . 2 . 3 . 119–27 . 2001 . 11426320 . 10.1038/sj.gene.6363745 . 23496123 . etal.
• Chen CY, Gherzi R, Ong SE . AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. . Cell . 107 . 4 . 451–64 . 2002 . 11719186 . 10.1016/S0092-8674(01)00578-5. 14817671 . etal. free .
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ . Protein-protein interactions of hCsl4p with other human exosome subunits. . J. Mol. Biol. . 315 . 4 . 809–18 . 2002 . 11812149 . 10.1006/jmbi.2001.5265 . 2066/261980 . free .
• Brouwer R, Vree Egberts WT, Hengstman GJ . Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. . Arthritis Res. . 4 . 2 . 134–8 . 2002 . 11879549 . 83843 . 10.1186/ar389. etal . free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. . J. Mol. Biol. . 323 . 4 . 653–63 . 2002 . 12419256 . 10.1016/S0022-2836(02)00947-6. 2066/186665 . free .
• Scherl A, Couté Y, Déon C . Functional proteomic analysis of human nucleolus. . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 133617 . 10.1091/mbc.E02-05-0271 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . etal. free .
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ . The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. . J. Biol. Chem. . 278 . 33 . 30698–704 . 2003 . 12788944 . 10.1074/jbc.M302488200 . free . 2066/186428 . free .
• Lejeune F, Li X, Maquat LE . Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. . Mol. Cell . 12 . 3 . 675–87 . 2003 . 14527413 . 10.1016/S1097-2765(03)00349-6. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 . etal.
• Raijmakers R, Renz M, Wiemann C . PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. . Arthritis Rheum. . 50 . 2 . 565–9 . 2004 . 14872500 . 10.1002/art.20056 . etal.
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation. . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 . etal.
• van Dijk EL, Schilders G, Pruijn GJ . Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. . RNA . 13 . 7 . 1027–35 . 2007 . 17545563 . 1894934 . 10.1261/rna.575107 .

Notes and References

1. Web site: Entrez Gene: EXOSC10 exosome component 10.