EXOC6 explained

Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene.^[1]

Function

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.

Further reading

• Zhang XM, Ellis S, Sriratana A, Mitchell CA, Rowe T . Sec15 is an effector for the Rab11 GTPase in mammalian cells . The Journal of Biological Chemistry . 279 . 41 . 43027–34 . October 2004 . 15292201 . 10.1074/jbc.M402264200 . free .
• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A . A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease . American Journal of Human Genetics . 78 . 1 . 78–88 . January 2006 . 16385451 . 1380225 . 10.1086/498851 .
• France YE, Boyd C, Coleman J, Novick PJ . The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit . Journal of Cell Science . 119 . Pt 5 . 876–88 . March 2006 . 16478783 . 10.1242/jcs.02849 . free .
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR . Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score . Molecular Medicine . 16 . 7–8 . 247–53 . 2010 . 20379614 . 2896464 . 10.2119/molmed.2009.00159 .
• Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E . Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst . Nature . 467 . 7317 . 854–8 . October 2010 . 20944747 . 10.1038/nature09446 . 5831355 . 2010Natur.467..854G .
• Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB . An integrative method for scoring candidate genes from association studies: application to warfarin dosing . BMC Bioinformatics . 11 . S9 . October 2010 . Suppl 9 . 21044367 . 2967750 . 10.1186/1471-2105-11-S9-S9 . free .

Notes and References

1. Web site: Entrez Gene: Exocyst complex component 6 .