EXOC5 explained

Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.^{[1] [2]}

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.^[2]

Interactions

EXOC5 has been shown to interact with Arf6.^[3]

References

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W . The exocyst complex in polarized exocytosis. . Int. Rev. Cytol. . 233 . 243–65 . 2004 . 15037366 . 10.1016/S0074-7696(04)33006-8 . International Review of Cytology . 978-0-12-364637-8 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH . Subunit structure of the mammalian exocyst complex. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 26 . 14438–43 . 1998 . 9405631 . 25013 . 10.1073/pnas.94.26.14438 . free . 1997PNAS...9414438K .
• Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH . Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments. . Neuron . 20 . 6 . 1111–22 . 1998 . 9655500 . 10.1016/S0896-6273(00)80493-6 . free .
• Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ . The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. . J. Biol. Chem. . 276 . 32 . 29792–7 . 2001 . 11406615 . 10.1074/jbc.C100320200 . free.
• Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ . Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. . Mol. Cell. Biol. . 22 . 6 . 1714–22 . 2002 . 11865051 . 135608 . 10.1128/MCB.22.6.1714-1722.2002 .
• Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR . The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. . Nature . 422 . 6932 . 629–33 . 2003 . 12687004 . 10.1038/nature01533 . 2003Natur.422..629I . 2027.42/62982 . 4395760 . free .
• Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA . Ral GTPases regulate exocyst assembly through dual subunit interactions. . J. Biol. Chem. . 278 . 51 . 51743–8 . 2004 . 14525976 . 10.1074/jbc.M308702200 . free .
• Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P . ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. . J. Cell Biol. . 163 . 5 . 1111–21 . 2004 . 14662749 . 2173613 . 10.1083/jcb.200305029 .
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . free .

Notes and References

1. Guo W, Roth D, Gatti E, De Camilli P, Novick P . Identification and characterization of homologues of the Exocyst component Sec10p . FEBS Lett . 404 . 2–3 . 135–9 . Apr 1997 . 9119050 . 10.1016/S0014-5793(97)00109-9 . 43733804 .
2. Web site: Entrez Gene: EXOC5 exocyst complex component 5.
3. Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P . ARF6 controls post-endocytic recycling through its downstream exocyst complex effector . J. Cell Biol. . 163 . 5 . 1111–21 . Dec 2003 . 14662749 . 2173613 . 10.1083/jcb.200305029 .