EXOC3L2 explained

Exocyst complex component 3-like 2 is a protein that in humans is encoded by the EXOC3L2 gene.^{[1] [2] [3]}

The EXOC3L2 protein has been shown to interact with EXOC4^[1] that is a component of the exocyst complex^{[4] [5]} involved exocytosis and more specifically in the targeting of exocytic vesicles to the cell membrane.

The exocyst complex is important for several biological processes, such as the establishment of cell polarity and regulation of cell migration.^{[4] [6]} The structure and functions of the exocyst complex are conserved from yeast to higher eukaryotes.^{[4] [5]} Endothelial cells in blood vessels express high levels of EXOC3L2 that is required for proper VEGFR-2^[1] signaling so that the endothelial cells can migrate towards the growth factor VEGF-A.^[7]

Notes and References

1. 21566143 . 2011 . Barkefors . I . Fuchs . PF . Heldin . J . Bergström . T . Forsberg-Nilsson . K . Kreuger . J . Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells . 286 . 27 . 24189–99 . 10.1074/jbc.M110.212209 . 3129200 . The Journal of Biological Chemistry. free .
2. 22191060 . 2011 . Olgiati . P . Politis . AM . Papadimitriou . GN . De Ronchi . D . Serretti . A . Genetics of late-onset Alzheimer's disease: Update from the alzgene database and analysis of shared pathways . 2011 . 832379 . 10.4061/2011/832379 . 3235576 . International Journal of Alzheimer's Disease . free .
3. 21132329 . 2011 . Belbin . O . Carrasquillo . MM . Crump . M . Culley . OJ . Hunter . TA . Ma . L . Bisceglio . G . Zou . F . Allen . M . Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease . 129 . 3 . 273–82 . 10.1007/s00439-010-0924-2 . 3036835 . Human Genetics .
4. 21997494 . 2011 . Liu . J . Guo . W . The exocyst complex in exocytosis and cell migration . 10.1007/s00709-011-0330-1 . Protoplasma. 249 . 3 . 587–597 . 11946932 .
5. 16826234 . 2006 . Munson . M . Novick . P . The exocyst defrocked, a framework of rods revealed . 13 . 7 . 577–81 . 10.1038/nsmb1097 . Nature Structural & Molecular Biology. 26645238 .
6. 22264730 . 2012 . Thapa . N . Sun . Y . Schramp . M . Choi . S . Ling . K . Anderson . RA . Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells . 22 . 1 . 116–30 . 10.1016/j.devcel.2011.10.030 . 3266520 . Developmental Cell.
7. 21593862 . 2011 . Carmeliet . P . Jain . RK . Molecular mechanisms and clinical applications of angiogenesis . 473 . 7347 . 298–307 . 10.1038/nature10144 . Nature. 4049445 . 2011Natur.473..298C .