EXOC3 explained

Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.^{[1] [2]}

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.

Interactions

EXOC3 has been shown to interact with DLG3^[3] and EXOC4.^{[3] [4]}

Further reading

• Book: Hsu SC, TerBush D, Abraham M, Guo W . Kwang J . The exocyst complex in polarized exocytosis . International Review of Cytology . 233 . 243–65 . 2004 . 15037366 . 10.1016/S0074-7696(04)33006-8 . 978-0-12-364637-8.
• Hsu SC, Ting AE, Hazuka CD, Davanger S, Kenny JW, Kee Y, Scheller RH . The mammalian brain rsec6/8 complex . Neuron . 17 . 6 . 1209–19 . 1997 . 8982167 . 10.1016/S0896-6273(00)80251-2 . 16295203 . free .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Kee Y, Yoo JS, Hazuka CD, Peterson KE, Hsu SC, Scheller RH . Subunit structure of the mammalian exocyst complex . Proc. Natl. Acad. Sci. U.S.A. . 94 . 26 . 14438–43 . 1998 . 9405631 . 25013 . 10.1073/pnas.94.26.14438 . free . 1997PNAS...9414438K .
• Hsu SC, Hazuka CD, Roth R, Foletti DL, Heuser J, Scheller RH . Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments . Neuron . 20 . 6 . 1111–22 . 1998 . 9655500 . 10.1016/S0896-6273(00)80493-6 . 10915358 . free .
• Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ . The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene . J. Biol. Chem. . 276 . 32 . 29792–7 . 2001 . 11406615 . 10.1074/jbc.C100320200 . free.
• Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ . Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles . Mol. Cell. Biol. . 22 . 6 . 1714–22 . 2002 . 11865051 . 135608 . 10.1128/MCB.22.6.1714-1722.2002 .
• Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR . The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin . Nature . 422 . 6932 . 629–33 . 2003 . 12687004 . 10.1038/nature01533 . 2003Natur.422..629I . 2027.42/62982 . 4395760 . free .
• Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O . Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones . DNA Res. . 10 . 1 . 49–57 . 2003 . 12693554 . 10.1093/dnares/10.1.49 . free .
• Wang S, Hsu SC . Immunological characterization of exocyst complex subunits in cell differentiation . Hybrid. Hybridomics . 22 . 3 . 159–64 . 2004 . 12954101 . 10.1089/153685903322286575 .
• Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA . Ral GTPases regulate exocyst assembly through dual subunit interactions . J. Biol. Chem. . 278 . 51 . 51743–8 . 2004 . 14525976 . 10.1074/jbc.M308702200 . free .

Notes and References

1. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal Biochem . 236 . 1 . 107–13 . Jun 1996 . 8619474 . 10.1006/abio.1996.0138 .
2. Web site: Entrez Gene: EXOC3 exocyst complex component 3.
3. Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ . NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex . Nat. Cell Biol. . 5 . 6 . 520–30 . Jun 2003 . 12738960 . 10.1038/ncb990 . 13444388 .
4. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR . The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin . . 422 . 6932 . 629–33 . Apr 2003 . 12687004 . 10.1038/nature01533 . 2003Natur.422..629I . 2027.42/62982 . 4395760 . free .