EXOC1 explained

Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene.^{[1] [2] [3]}

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W . The exocyst complex in polarized exocytosis . Int. Rev. Cytol. . 233 . 243–65 . 2004 . 15037366 . 10.1016/S0074-7696(04)33006-8 . International Review of Cytology . 978-0-12-364637-8 .
• Kee Y, Yoo JS, Hazuka CD . Subunit structure of the mammalian exocyst complex . Proc. Natl. Acad. Sci. U.S.A. . 94 . 26 . 14438–43 . 1998 . 9405631 . 10.1073/pnas.94.26.14438 . 25013 . etal. free .
• Hsu SC, Hazuka CD, Roth R . Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments . Neuron . 20 . 6 . 1111–22 . 1998 . 9655500 . 10.1016/S0896-6273(00)80493-6 . 10915358 . etal. free .
• Matern HT, Yeaman C, Nelson WJ, Scheller RH . The Sec6/8 complex in mammalian cells: Characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells . Proc. Natl. Acad. Sci. U.S.A. . 98 . 17 . 9648–53 . 2001 . 11493706 . 10.1073/pnas.171317898 . 55506 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Inoue M, Chang L, Hwang J . The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin . Nature . 422 . 6932 . 629–33 . 2003 . 12687004 . 10.1038/nature01533 . 2003Natur.422..629I . etal. 2027.42/62982 . 4395760 . free .
• Moskalenko S, Tong C, Rosse C . Ral GTPases regulate exocyst assembly through dual subunit interactions . J. Biol. Chem. . 278 . 51 . 51743–8 . 2004 . 14525976 . 10.1074/jbc.M308702200 . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z . Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells . Genome Res . 10 . 10 . 1546–60 . Nov 2000 . 11042152 . 310934 . 10.1101/gr.140200 .
2. Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ . The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene . J Biol Chem . 276 . 32 . 29792–7 . Aug 2001 . 11406615 . 10.1074/jbc.C100320200 . free.
3. Web site: Entrez Gene: EXOC1 exocyst complex component 1.