Envoplakin Explained

Envoplakin is a protein that in humans is encoded by the EVPL gene.^{[1] [2] [3]}

Interactions

Envoplakin has been shown to interact with PPL.^{[4] [5]}

See also

• List of target antigens in pemphigus

Further reading

• Ruhrberg C, Hajibagheri MA, Simon M . Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin. . J. Cell Biol. . 134 . 3 . 715–29 . 1996 . 8707850 . 10.1083/jcb.134.3.715 . 2120946 . etal.
• Steinert PM, Marekov LN . Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. . J. Biol. Chem. . 272 . 3 . 2021–30 . 1997 . 8999895 . 10.1074/jbc.272.3.2021 . free .
• Robinson NA, Lapic S, Welter JF, Eckert RL . S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. . J. Biol. Chem. . 272 . 18 . 12035–46 . 1997 . 9115270 . 10.1074/jbc.272.18.12035 . free .
• Ruhrberg C, Hajibagheri MA, Parry DA, Watt FM . Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. . J. Cell Biol. . 139 . 7 . 1835–49 . 1998 . 9412476 . 10.1083/jcb.139.7.1835 . 2132639 .
• Marekov LN, Steinert PM . Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope. . J. Biol. Chem. . 273 . 28 . 17763–70 . 1998 . 9651377 . 10.1074/jbc.273.28.17763 . free .
• Määttä A, Ruhrberg C, Watt FM . Structure and regulation of the envoplakin gene. . J. Biol. Chem. . 275 . 26 . 19857–65 . 2000 . 10747979 . 10.1074/jbc.M001028200 . free .
• Lee CH, Marekov LN, Kim S . Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes. . FEBS Lett. . 477 . 3 . 268–72 . 2000 . 10908733 . 10.1016/S0014-5793(00)01806-8 . 12228606 . etal. free .
• DiColandrea T, Karashima T, Määttä A, Watt FM . Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope. . J. Cell Biol. . 151 . 3 . 573–86 . 2000 . 11062259 . 10.1083/jcb.151.3.573 . 2185584 .
• Kazerounian S, Uitto J, Aho S . Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin. . Exp. Dermatol. . 11 . 5 . 428–38 . 2003 . 12366696 . 10.1034/j.1600-0625.2002.110506.x . 25735126 .
• Karashima T, Watt FM . Interaction of periplakin and envoplakin with intermediate filaments. . J. Cell Sci. . 115 . Pt 24 . 5027–37 . 2003 . 12432088 . 10.1242/jcs.00191 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Kalinin AE, Idler WW, Marekov LN . Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia. . J. Biol. Chem. . 279 . 21 . 22773–80 . 2004 . 15033990 . 10.1074/jbc.M313660200 . etal. free .
• Suzuki Y, Yamashita R, Shirota M . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 . etal.
• Iwaya T, Maesawa C, Kimura T . Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas. . Oncol. Rep. . 13 . 4 . 703–7 . 2005 . 15756445 . 10.3892/or.13.4.703. etal.

Notes and References

1. Ruhrberg C, Williamson JA, Sheer D, Watt FM . Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25 . Genomics . 37 . 3 . 381–5 . Mar 1997 . 8938451 . 10.1006/geno.1996.0573 .
2. Risk JM, Ruhrberg C, Hennies H, Mills HS, Di Colandrea T, Evans KE, Ellis A, Watt FM, Bishop DT, Spurr NK, Stevens HP, Leigh IM, Reis A, Kelsell DP, Field JK . Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25 . Genomics . 59 . 2 . 234–42 . Sep 1999 . 10409435 . 10.1006/geno.1999.5857 .
3. Web site: Entrez Gene: EVPL envoplakin.
4. Karashima . Tadashi . Watt Fiona M . Dec 2002 . Interaction of periplakin and envoplakin with intermediate filaments . J. Cell Sci. . 115 . Pt 24 . 5027–37 . 0021-9533. 12432088 . 10.1242/jcs.00191 . free .
5. Ruhrberg . C . Hajibagheri M A . Parry D A . Watt F M . Dec 1997 . Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin . J. Cell Biol. . 139 . 7 . 1835–49 . 0021-9525. 9412476 . 10.1083/jcb.139.7.1835 . 2132639 .